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Thromb Haemost 1983; 50(03): 671-675
DOI: 10.1055/s-0038-1665284
Original Article
Schattauer GmbH Stuttgart

The Effects of Prostacyclin on the Coagulation of Whole Blood

D S Holloway
1   The Biomedical Engineering Center, Northwestern University, Evanston, IL, U.S.A.
2   The Coagulation Research Laboratory, Evanston Hospital, Evanston, IL, U.S.A.
,
L Zuckerman
3   The Department of Surgery, Loyola University Medical Center, Maywood, IL, U.S.A.
,
J P Vagher
2   The Coagulation Research Laboratory, Evanston Hospital, Evanston, IL, U.S.A.
,
L F Mockros
1   The Biomedical Engineering Center, Northwestern University, Evanston, IL, U.S.A.
› Author Affiliations
Further Information

Publication History

Received 12 August 1982

Accepted 15 July 1983

Publication Date:
18 July 2018 (online)

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Summary

The effects of prostacyclin (PGI2) on mechanical properties of forming clots were investigated by testing human blood samples on a Thrombelastograph. Concentrations greater than 50 ng/ml (blood) caused a biphasic development of clot stiffness. During the first phase, PGI2 partially inhibited the platelet involvement in coagulation causing initial clot formation at a normal time but with reduced clot stiffness. The second phase occurred after neutralization of PGI2 activity and was characterized by recovery of platelet activity to produce a final clot with normal shear modulus. The duration of the inhibitory effects depended on PGI2 concentration and hematocrit. With a normal hematocrit, a PGI2 concentration of 60 ng/ml caused an inhibition for about 40 min whereas a concentration of 100 ng/ml caused inhibition for about 75 min.

Keywords

Prostacyclin - Platelet - Thrombelastography
 

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