Thromb Haemost 1986; 55(03): 330-332
DOI: 10.1055/s-0038-1661557
Original Article
Schattauer GmbH Stuttgart

Increase in Plasma Concentrationof Plasminogen Activator Inhibitor, Fibrinogen, von Willebrand Factor, Factor VIII: Cand in Erythrocyte Sedimentation Rate with Age

M F Aillaud
1  The Laboratory of Haematology, Hospital Timone, University of Marseille, Marseille, France
,
F Pignol
2  The Dept. of Geriatry, Hospital Nord, University of Marseille, Marseille, France
,
M C Alessi
1  The Laboratory of Haematology, Hospital Timone, University of Marseille, Marseille, France
,
J R Harle
3  The Dept, of Internal Medicine, Hospital Timone, University of Marseille, Marseille, France
,
M Escande
4  The Geriatric Center Allauch, Marseille, France
,
M Mongin
3  The Dept, of Internal Medicine, Hospital Timone, University of Marseille, Marseille, France
,
I Juhan-Vague
1  The Laboratory of Haematology, Hospital Timone, University of Marseille, Marseille, France
› Institutsangaben
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Publikationsverlauf

Received 26. November 1985

Accepted 14. März 1986

Publikationsdatum:
18. Juli 2018 (online)

Summary

Elderly patients have previously been shown to have an increased plasma concentration of tissue plasminogen activator (t-PA) antigen (t-PAAg). Since the concentration of t-PA Ag dependson both free t-PA and t-PA complexed with inhibitors, mainly plasminogen activator inhibitor (PA inhibitor), we have investigated the relationship between the plasma concentration of PA inhibitor and age in 20 elderly and 20 young individuals. Elderly individuals showed a slight increase in PA inhibitor, in parallel with increase on others, acute-phase proteins, fibrinogen, von Willebrand factor, factor VIII :C, and the erythrocyte sedimentation rate. The increase i PA inhibitor as well as other acute-phase proteins in the elderly may be significant in relation to the increased incidence of thrombotic disease.