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Thromb Haemost 1986; 55(01): 104-107
DOI: 10.1055/s-0038-1661457
Original Article
Schattauer GmbH Stuttgart

Intra-Operative Activation of Coagulation - A Stimulus to Thrombosis Mediated by Vasopressin?

P J Grant
The University Departments of Medicine, The General Infirmary, Leeds, UK
,
G M Tate
The University Departments of Medicine, The General Infirmary, Leeds, UK
,
J A Davies
The University Departments of Medicine, The General Infirmary, Leeds, UK
,
N S Williams
*   The University Departments of Surgery, The General Infirmary, Leeds, UK
,
C R M Prentice
The University Departments of Medicine, The General Infirmary, Leeds, UK
› Author Affiliations
Further Information

Publication History

Received 22 August 1985

Accepted 14 November 1985

Publication Date:
19 July 2018 (online)

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Summary

Vasopressin infusions in normal volunteers that produce concentrations in plasma comparable to those seen during stress, cause an increase in plasma factor VIII and shortening of the euglobulin clot lysis time (ECLT). We have investigated the relationship between endogenous vasopressin (aVP) release and haemostatic function in 7 patients undergoing major abdominal surgery. Blood samples were taken at nine intervals during the operative procedure. Plasma aVP levels peaked at median values of 51 pg/ml during bowel manipulation and remained elevated on the first post-operative day. Following, and in close temporal relationship with the rise in aVP there were increases in factor VIII coagulant activity, the ristocetin co-factor, von Willebrand antigen, plasminogen activator activity (106/ECLT2) and fibrinopeptide A concentrations with shortening of the activated partial thromboplastin time. The relationship was similar to that seen following infusion of a VP in human volunteers. The results are consistent with the hypothesis that aVP is an important mediator of changes in haemostatic function which accompany stress and might contribute to the thrombotic risk associated with surgical operations.

Key words

Abdominal surgery - Vasopressin - Factor VIII - Fibrinolysis - Fibrinopeptide A
 

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