Effect of Dietary Vitamin E on the Production of Platelet 12-Hydroxyeicosatetraenoic Acid (12-HETE)

Summary

Collagen and thrombin challenged platelets from vitamin E-deficient rabbits generated significantly more 12-HETE when compared to the platelets from vitamin E-supplemented rabbits. Similarly, conversion of arachidonic acid to 12-HETE was increased in platelets from vitamin E-deficient rabbits. These data show that vitamin E plays a role not only in deacylation of platelet phospholipids but also in the lipoxygenase mediated reactions.

Key words

Rabbit - Platelets - Vitamin E - 12-HETE

• References

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