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Thromb Haemost 1986; 55(01): 006-007
DOI: 10.1055/s-0038-1661435
Original Article
Schattauer GmbH Stuttgart

Effect of Dietary Vitamin E on the Production of Platelet 12-Hydroxyeicosatetraenoic Acid (12-HETE)

K A Pritchard
The Department of Physiological Chemistry, Columbus, Ohio, USA
,
N J Greco
The Department of Physiological Chemistry, Columbus, Ohio, USA
,
R V Panganamala
The Department of Physiological Chemistry, Columbus, Ohio, USA
› Author Affiliations
Further Information

Publication History

Received 04 December 1984

Accepted 13 September 1985

Publication Date:
19 July 2018 (online)

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Summary

Collagen and thrombin challenged platelets from vitamin E-deficient rabbits generated significantly more 12-HETE when compared to the platelets from vitamin E-supplemented rabbits. Similarly, conversion of arachidonic acid to 12-HETE was increased in platelets from vitamin E-deficient rabbits. These data show that vitamin E plays a role not only in deacylation of platelet phospholipids but also in the lipoxygenase mediated reactions.

Key words

Rabbit - Platelets - Vitamin E - 12-HETE
 

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