Thromb Haemost 1985; 53(02): 242-244
DOI: 10.1055/s-0038-1661284
Original Article
Schattauer GmbH Stuttgart

Cold Promoted Activation and Factor XII, Prekallikrein and C1-Inhibitor

C Czendlik
The Coagulation and Fibrinolysis Laboratory, Kantonsspital, Basel, Switzerland
,
B Lämmle
The Coagulation and Fibrinolysis Laboratory, Kantonsspital, Basel, Switzerland
,
F Ducket
The Coagulation and Fibrinolysis Laboratory, Kantonsspital, Basel, Switzerland
› Author Affiliations
Further Information

Publication History

Received 10 October 1984

Accepted 02 February 1985

Publication Date:
18 July 2018 (online)

Summary

During incubation of plasma in the cold an amidolytic activity due to the kallikrein-α2-macroglobulin complex appears in the plasma of about 40% of the women under hormonal contraception. The factor XII and prekallikrein activity are significantly increased 151.9% and 112.4% respectively in the cold promoted activation positive plasmas (CPA pos) whereas the activity of C1-inhibitor is decreased, 76%. The quotient of the product of the C1-inhibitor and α2-macroglobulin values divided by the product of the FXII and prekallikrein values is significantly lower in the CPA pos plasma 0.49 than in CPA neg plasma 0.96 (p <0.05). These results alone do not explain the cold promoted activation, since a patient with a C1-inhibitor as low as 9% showed no increase of the amidolytic activity after a 24 hr incubation at 4° C. However, the addition of purified C1-inhibitor to a CPA pos. plasma inhibits the cold activation. Heparin at a concentration of 0.5 IU/ml delays the appearance of the amidolytic activity.

 
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