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Thromb Haemost 1985; 53(02): 212-215
DOI: 10.1055/s-0038-1661276
Original Article
Schattauer GmbH Stuttgart

Fibrinogen Fragments X, Y, D and E Increase Levels of Plasma Fibrinogen and Liver mRNAs Coding for Fibrinogen Polypeptides in Rats

H M G Princen
1   The Gaubius Institute, Health Research Division TNO, Leiden, The Netherlands
,
H J Moshage
The Division of Gastrointestinal and Liver Disease, Dept. of Medicine, St. Radboud Hospital, University of Nijmegen, Nijmegen, The Netherlands
,
J J Emeis
1   The Gaubius Institute, Health Research Division TNO, Leiden, The Netherlands
,
H J W de Haard
The Division of Gastrointestinal and Liver Disease, Dept. of Medicine, St. Radboud Hospital, University of Nijmegen, Nijmegen, The Netherlands
,
W Nieuwenhuizen
1   The Gaubius Institute, Health Research Division TNO, Leiden, The Netherlands
,
S H Yap
The Division of Gastrointestinal and Liver Disease, Dept. of Medicine, St. Radboud Hospital, University of Nijmegen, Nijmegen, The Netherlands
› Author Affiliations
Further Information

Publication History

Received 14 August 1984

Accepted 01 January 1985

Publication Date:
18 July 2018 (online)

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Summary

Previously, we demonstrated that in vivo regulation of liver fibrinogen synthesis occurs via the fibrinogen mRNA level. However, the molecular regulatory mechanism of fibrinogen synthesis is still not well understood. Fibrinogen or fibrin degradation products might play an important role in regulating fibrinogen synthesis. In our present study, we have injected rats intraperitoneally with purified homologous fragments and measured the liver content of mRNA specific coding for fibrinogen. Increased levels of fibrinogen mRNA and elevated plasma fibrinogen concentrations were observed in rats after administration of fibrinogen degradation products X, Y, DEGTA Dcate or E. Fragment E or E’ has a less stimulatory effect than X, Y or Dcate, whereas cross-linked fibrin degradation product D dimer does not increase fibrinogen synthesis. This article reports for the first time a stimulatory effect of the high molecular weight fibrinogen degradation products on fibrinogen synthesis.

Keywords

Fibrinogen mRNA - Fibrinogen synthesis - Fibrinogen fragments - Fibrin degradation products - Isolated hepatocytes
 

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