Fibrinolytic Activators and Inhibitors in Terminal Renal Insufficiency and in Anephric Patients

Summary

Fibrinolytic factors were measured before and after DDAVP- infusion in 18 patients on chronic, regular haemodialysis, 11 of whom underwent bilateral nephrectomy, and in 7 patients in whom non-functioning kidneys were still present. Baseline fibrinolytic activity was normal or high in all but two cases. Before haemodialysis, the response to DDAVP-infusion was greatly reduced in the majority of patients as compared with healthy controls, irrespective of the baseline level. This was in accordance with mean t-PA-antigen levels which increased only slightly after DDAVP. When DDAVP was given after haemodialysis, previous non-responders showed a normal increase in fibrinolytic activity. The level of free t-PA-inhibitors was normal in most cases as were levels of α₂-antiplasmin. and α₂-macroglobulin.

Key words

Plasminogen activator - t-PA-inhibitor - Haemodialysis - Nephrectomy - DDAVP

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