Thromb Haemost 1984; 52(03): 311-314
DOI: 10.1055/s-0038-1661203
Original Article
Schattauer GmbH Stuttgart

Fibrinolytic Activators and Inhibitors in Terminal Renal Insufficiency and in Anephric Patients

E J P Brommer
The Gaubius Institute, Health Research Division TNO, Leiden, The Netherlands
,
I Schicht
*   The Dept. of Nephrology, Academic Hospital, Leiden, The Netherlands
,
G Wijngaards
The Gaubius Institute, Health Research Division TNO, Leiden, The Netherlands
,
J H Verheijen
The Gaubius Institute, Health Research Division TNO, Leiden, The Netherlands
,
D C Rijken
The Gaubius Institute, Health Research Division TNO, Leiden, The Netherlands
› Author Affiliations
Further Information

Publication History

Received 03 August 1984

Accepted 24 September 1984

Publication Date:
19 July 2018 (online)

Summary

Fibrinolytic factors were measured before and after DDAVP- infusion in 18 patients on chronic, regular haemodialysis, 11 of whom underwent bilateral nephrectomy, and in 7 patients in whom non-functioning kidneys were still present. Baseline fibrinolytic activity was normal or high in all but two cases. Before haemodialysis, the response to DDAVP-infusion was greatly reduced in the majority of patients as compared with healthy controls, irrespective of the baseline level. This was in accordance with mean t-PA-antigen levels which increased only slightly after DDAVP. When DDAVP was given after haemodialysis, previous non-responders showed a normal increase in fibrinolytic activity. The level of free t-PA-inhibitors was normal in most cases as were levels of α2-antiplasmin. and α2-macroglobulin.

 
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