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Thromb Haemost 1984; 52(03): 221-223
DOI: 10.1055/s-0038-1661181
Original Article
Schattauer GmbH Stuttgart

The Contact Phase of Blood Coagulation in Diabetes Mellitus and in Patients with Vasculopathy

M Christe
The Gerinnungs- und Fibrinolyselabor, Kantonsspital, Basel, Switzerland
,
P Gattlen
The Gerinnungs- und Fibrinolyselabor, Kantonsspital, Basel, Switzerland
,
J Fritschi
The Gerinnungs- und Fibrinolyselabor, Kantonsspital, Basel, Switzerland
,
B Lämmle
The Gerinnungs- und Fibrinolyselabor, Kantonsspital, Basel, Switzerland
,
W Berger
The Gerinnungs- und Fibrinolyselabor, Kantonsspital, Basel, Switzerland
,
G A Marbet
The Gerinnungs- und Fibrinolyselabor, Kantonsspital, Basel, Switzerland
,
F Duckert
The Gerinnungs- und Fibrinolyselabor, Kantonsspital, Basel, Switzerland
› Author Affiliations
Further Information

Publication History

Received 04 April 1984

Accepted 25 July 1984

Publication Date:
19 July 2018 (online)

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Summary

The contact phase has been studied in diabetics and patients with macroangiopathy. Factor XII and high molecular weight kininogen (HMWK) are normal. C1-inhibitor and also α2-macroglobulin are significantly elevated in diabetics with complications, for α1-macroglobulin especially in patients with nephropathy, 137.5% ± 36.0 (p <0.001). C1-inhibitor is also increased in vasculopathy without diabetes 113.2 ± 22.1 (p <0.01).

Prekallikrein (PK) is increased in all patients’ groups (Table 2) as compared to normals. PK is particularly high (134% ± 32) in 5 diabetics without macroangiopathy but with sensomotor neuropathy. This difference is remarkable because of the older age of diabetics and the negative correlation of PK with age in normals.

Key words

Diabetes mellitus - Neuropathy - Prekallikrein - Contact phase
 

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