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Thromb Haemost 1984; 52(02): 127-130
DOI: 10.1055/s-0038-1661155
Original Article
Schattauer GmbH Stuttgart

Impaired Fibrinolytic Capacity Predisposes for Recurrence of Venous Thrombosis

C Korninger
1   The 1st Department of Medicine1 (Head: Prof. Dr. Dr. h. c. E. Deutsch) Division of Haematology and Blood Coagulation, University of Vienna, Austria
,
K Lechner
1   The 1st Department of Medicine1 (Head: Prof. Dr. Dr. h. c. E. Deutsch) Division of Haematology and Blood Coagulation, University of Vienna, Austria
,
H Niessner
1   The 1st Department of Medicine1 (Head: Prof. Dr. Dr. h. c. E. Deutsch) Division of Haematology and Blood Coagulation, University of Vienna, Austria
,
H Gössinger
1   The 1st Department of Medicine1 (Head: Prof. Dr. Dr. h. c. E. Deutsch) Division of Haematology and Blood Coagulation, University of Vienna, Austria
,
M Kundi
2   The Department of Environmental Hygiene, University of Vienna, Austria
› Author Affiliations
Further Information

Publication History

Received 23 February 1984

Accepted 23 June 1984

Publication Date:
19 July 2018 (online)

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Summary

The fibrinolytic capacity of 121 patients with a history of venous thrombosis and/or pulmonary embolism was studied by venous occlusion technique, at earliest 3 months after the last thromboembolic episode. After discontinuation of oral anticoagulation treatment the clinical course of the patients was followed and new thromboembolic episodes were noted. During the observation period of 56 ± 18.8 months 45 of 121 patients experienced recurrence of thrombosis. The recurrence-rate was significantly lower in patients with a post-occlusion ELT shorter than 60 min (4.8%/year) than in patients with an ELT longer than 60 min (10.3%/year). It is concluded that the fibrinolytic capacity is a useful parameter for determining the risk of recurrence in patients with venous thrombosis.

Keywords

Tissue-type plasminogen activator - Fibrinolytic capacity-venous thrombosis - Recurrence
 

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