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Thromb Haemost 1984; 52(02): 124-126
DOI: 10.1055/s-0038-1661154
Original Article
Schattauer GmbH Stuttgart

The Fast Inhibitor of Tissue Plasminogen Activator in Plasma During Pregnancy

B Wiman
The Department of Clinical Chemistry and Blood Coagulation, Karolinska Hospital, Stockholm, Sweden
,
G Csemiczky
*   The Department of Obstetrics and Gynecology, Karolinska Hospital, Stockholm, Sweden
,
L Marsk
*   The Department of Obstetrics and Gynecology, Karolinska Hospital, Stockholm, Sweden
,
H Robbe
*   The Department of Obstetrics and Gynecology, Karolinska Hospital, Stockholm, Sweden
› Author Affiliations
Further Information

Publication History

Received 30 November 1983

Accepted 23 June 1984

Publication Date:
19 July 2018 (online)

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Summary

The novel fast inhibitor to tissue plasminogen activator in plasma has been determined in 20 healthy non-pregnant women, 48 apparently healthy pregnant women and 136 women with risk pregnancies (preeclampsia, suspected fetal growth retardation, thrombosis or previous history of thrombosis, diabetes and others). In healthy fertile non-pregnant women, the inhibitor concentration was found to be 0.4 ± 0.7 U/ml. In pregnant women the concentration stayed at this level until week 10, but then an almost linear increase was found, reaching about 6.5 U/ml at week 40. In plasma samples from the patients with risk pregnancies many with deviating concentrations were found. Thus, in the last trimester a range of 0-24.0 U/ml was found in these patients, as compared to 4.0-6.4 U/ml in healthy pregnant women. The pathophysiological impact of this finding is at present unclear.

Keywords

Fibrinolysis - Plasminogen activator inhibition - Pregnancy - Risk pregnancy
 

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