Thromb Haemost 1984; 52(02): 121-123
DOI: 10.1055/s-0038-1661153
Original Article
Schattauer GmbH Stuttgart

Venous Thrombosis Following Diagnostic Transvenous Catheterization by Percutaneous Catheter Insertion: An Evaluation of Desmopressin as a Thromboprophylactic Agent

D W T Nilsen
The Haematological Research Laboratory, Ullevål Hospital, Oslo, Norway
,
J Haerem
1   The Department of Cardiology, Ullevål Hospital, Oslo, Norway
,
A Westheim
2   The Laboratory of Clinical Physiology, Ullevål Hospital, Oslo, Norway
,
A Skjennald
3   The Department of Radiology, Ullevål Hospital, Oslo, Norway
,
H Grendahl
1   The Department of Cardiology, Ullevål Hospital, Oslo, Norway
,
H C Godal
The Haematological Research Laboratory, Ullevål Hospital, Oslo, Norway
› Author Affiliations
Further Information

Publication History

Received 16 April 1984

Accepted 20 June 1984

Publication Date:
19 July 2018 (online)

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Summary

The preventive effect of desmopressin with respect to catheter induced thrombosis was studied in a randomized double-blind trial, consisting of 30 patients undergoing percutaneous transcubital right heart catheterization. Phlebography of the catheterized arm was performed after five days. The frequency of postcatheterization thrombosis was reduced by 33 per cent, from 86 per cent in the treatment group to 53 per cent in the control group (0.1 <p <0.2). This effect was restricted to minor thrombi, whereas major thrombosis could not be prevented.

Patient materials such as that of the present study, may become useful in preliminary investigations of thromboprophylactic agents.