Triglyceride-Rich Lipoproteins Are Responsible for Thrombin Generation Induced by Lipid Peroxides

T W Barrowcliffe; E Gray; P J Kerry; J M C Gutteridge

doi:10.1055/s-0038-1661124

Thrombosis and Haemostasis, Table of Contents

Thromb Haemost 1984; 52(01): 007-010
DOI: 10.1055/s-0038-1661124

Original Article

Schattauer GmbH Stuttgart

Triglyceride-Rich Lipoproteins Are Responsible for Thrombin Generation Induced by Lipid Peroxides

T W Barrowcliffe

The National Institute for Biological Standards and Control, Hampstead, London, U.K.

,

E Gray

The National Institute for Biological Standards and Control, Hampstead, London, U.K.

,

P J Kerry

The National Institute for Biological Standards and Control, Hampstead, London, U.K.

,

J M C Gutteridge

The National Institute for Biological Standards and Control, Hampstead, London, U.K.

› Author Affiliations

Abstract

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Summary

Previous studies have shown that lipid peroxides promote thrombin generation in platelet-poor plasma. In the present study, it has been shown that triglyceride-rich lipoproteins, especially chylomicra of dietary origin, are responsible for this procoagulant activity. The generation of thrombin by lipid peroxides is also enhanced by their inhibitory action on antithrombin III. These results suggest a possible new relationship between dietary fat, lipid peroxidation and thrombus formation.

Keywords

Lipid peroxides - Lipoproteins - Coagulation

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References

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