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Thromb Haemost 1984; 52(01): 007-010
DOI: 10.1055/s-0038-1661124
Original Article
Schattauer GmbH Stuttgart

Triglyceride-Rich Lipoproteins Are Responsible for Thrombin Generation Induced by Lipid Peroxides

T W Barrowcliffe
The National Institute for Biological Standards and Control, Hampstead, London, U.K.
,
E Gray
The National Institute for Biological Standards and Control, Hampstead, London, U.K.
,
P J Kerry
The National Institute for Biological Standards and Control, Hampstead, London, U.K.
,
J M C Gutteridge
The National Institute for Biological Standards and Control, Hampstead, London, U.K.
› Author Affiliations
Further Information

Publication History

Received 24 February 1984

Accepted 27 April 1984

Publication Date:
19 July 2018 (online)

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Summary

Previous studies have shown that lipid peroxides promote thrombin generation in platelet-poor plasma. In the present study, it has been shown that triglyceride-rich lipoproteins, especially chylomicra of dietary origin, are responsible for this procoagulant activity. The generation of thrombin by lipid peroxides is also enhanced by their inhibitory action on antithrombin III. These results suggest a possible new relationship between dietary fat, lipid peroxidation and thrombus formation.

Keywords

Lipid peroxides - Lipoproteins - Coagulation
 

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