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Thromb Haemost 1984; 52(01): 004-006
DOI: 10.1055/s-0038-1661123
Original Article
Schattauer GmbH Stuttgart

Pressure-Induced Metabolic Activation of Platelets Demonstrated In Vitro by Determination of Malondialdehyde Formation

Alessandro Torsellini
The Institute of Clinica Medica II, University of Florence, Florence, Italy
,
Luca Doni
The Institute of Clinica Medica II, University of Florence, Florence, Italy
,
Wulf Palinski
The Institute of Clinica Medica II, University of Florence, Florence, Italy
,
Giovanni Guidi
The Institute of Clinica Medica II, University of Florence, Florence, Italy
,
Valeriano Lombardi
The Institute of Clinica Medica II, University of Florence, Florence, Italy
› Author Affiliations
Further Information

Publication History

Received 16 January 1984

Accepted 25 April 1984

Publication Date:
19 July 2018 (online)

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Summary

Platelet rich plasma (PRP) exposed in vitro to 200 mm Hg above atmospheric pressure showed a significant increase in malondialdehyde (MDA) formation compared to PRP at atmospheric pressure. This difference is also evident when platelets are incubated with arachidonic acid.

The increase of MDA demonstrates that the increased beta- thromboglobulin and platelet factor 4 in plasma and the shape changes of platelets after pressure stimulation in vitro that were described in a previous paper result from the release reaction.

Pressure-induced effects in vivo are discussed

Keywords

Platelet function - Hypertension - Haemorheology
 

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