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Thromb Haemost 1984; 51(02): 192-195
DOI: 10.1055/s-0038-1661056
Original Article
Schattauer GmbH Stuttgart

A New Platelet Aggregating Material (PAM) in an Experimentally Induced Rat Fibrosarcoma

D Mohanty
The Royal Postgraduate Medical School, Hammersmith Hospital, London, U.K.
,
P Hilgard
The Royal Postgraduate Medical School, Hammersmith Hospital, London, U.K.
› Author Affiliations
Further Information

Publication History

Received 03 October 1983

Accepted 14 January 1984

Publication Date:
19 July 2018 (online)

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Summary

The present work concerns our studies to search for factor(s) which may influence the hemostatic process in or around metastasis of tumours. We studied the platelet aggregating property of a methyl cholanthrene induced experimental tumour. Platelet aggregating material was found to be different from the known aggregating agents like thrombin, ADP, collagen, thromboxane A2 and trypsin. It depends on a critical level of calcium for its action. PAM is a high molecular weight substance which contains sialic acid. It is trypsin and plasmin insensitive. The activity of this substance is not being destroyed by phospholipase-C. Metabolic study indicates that PAM acts by mitochondrial energy metabolic pathway of the platelets.

Keywords

Platelet aggregating material (PAM) - Tumour extract - Inhibitors of PAM
 

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