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Thromb Haemost 1984; 51(02): 150-153
DOI: 10.1055/s-0038-1661047
Original Article
Schattauer GmbH Stuttgart

Comparison Between Vascular Plasminogen Activator Activity and Changes in Blood Flow in the Renal Cortex in Pigs

Athanasios Smokovitis
*   The Department of Physiology, Faculty of Veterinary Medicine, Aristotelian University of Thessaloniki, Greece
,
Manfred Maier
**   The Department of Medical Physiology, School of Medicine, University of Vienna, Austria
,
Bernd R Binder
**   The Department of Medical Physiology, School of Medicine, University of Vienna, Austria
› Author Affiliations
Further Information

Publication History

Received 22 August 1983

Accepted 19 December 1983

Publication Date:
19 July 2018 (online)

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Summary

Patterns of vascular plasminogen activator activity (PAA) and of blood flow were compared in the renal cortex of pigs. The comparison was made in pigs with or without induction of hemorrhagic hypotension and continuous infusion of indomethacin (prostaglandin synthetase inhibitor) or saralasin (competitive inhibitor of angiotensin II). Blood flow was measured by radiolabelled microspheres. A significant decrease in the vascular PAA was observed only in saralasin treated animals (15% in not hemorrhaged pigs and 30% in the inner and 45% in the outer half of the renal cortex in hemorrhaged pigs). Changes in plasmin inhibitor activity in the renal cortex were not noted. No correlation could be seen between vascular PAA and changes in blood flow in the renal cortex or changes in the mean arterial blood pressure. The vascular fibrinolytic response to saralasin should be due to an effect of saralasin independent of the changes in blood flow induced by this agent.

Keywords

Blood flow - Renal cortex - Fibrinolysis - Indomethacin - Saralasin
 

  • References

  • 1 Warren DJ, Ledingham JG G. Renal vascular response to haemorrhage in the rabbit after pentobarbitone, chloralose-urethane and other anaesthesias. Clin Sci Mol Med 1978; 54: 489-494
    PubMedGoogle Scholar
  • 2 Errington ML, Rocha e Silva M. On the role of vasopressin and angiotensin in the development of irreversible haemorrhagic shock. J Physiol 1974; 242: 119-141
    CrossrefPubMedGoogle Scholar
  • 3 Collier JG, Herman AJ, Vane JR. Appearance of prostaglandins in the renal venous blood of dogs in response to acute systemic hypotension produced by bleeding or endotoxin. J Physiol 1973; 230: 19P-20P
    PubMedGoogle Scholar
  • 4 Cagnon JA, Keller HI, Kokotis W, Schrier RW. Analysis of role of renin-angiotensin system in autoregulation of glomerular filtration. Am J Physiol 1970; 219: 491-496
    PubMedGoogle Scholar
  • 5 Chang LC T, Splawinski JA, Oates JA, Nies AS. Enhanced renal prostaglandin production in the dog. II. Effects on intrarenal hemodynamics. Circ Res 1975; 36: 204-207
    CrossrefPubMedGoogle Scholar
  • 6 Data JL, Chang LC T, Nies AS. Alteration of canine renal vascular response to hemorrhage by inhibitors of prostaglandin synthesis. Am J Physiol 1975; 230: 940-945
    PubMedGoogle Scholar
  • 7 Thurau K. Renal hemodynamics. Am J Med 1964; 36: 698-719
    CrossrefPubMedGoogle Scholar
  • 8 Cash JD. Control mechanism of activator release. In: Progress in Chemical Fibrinolysis and Thrombolysis. Davidson JF, Rowan RM, Samama MM, Desnoyers PC. (eds) Raven Press; New York: 1978. 3 65-75
    Google Scholar
  • 9 Holemans R. Enhancement of fibrinolysis in the dog by injection of vasoactive drugs. Am J Physiol 1965; 208: 511-520
    PubMedGoogle Scholar
  • 10 Izaki S, Kitaguchi H. Calcium dependent and independent release of plasminogen activator from the vascular wall. Thromb Res 1977; 10: 765-770
    CrossrefPubMedGoogle Scholar
  • 11 Markwardt F, Klöcking HP. Studies on the release of plasminogen activator. Thromb Res 1976; 8: 217-223
    PubMedGoogle Scholar
  • 12 Rosing DR, Redwood DR, Brakman P, Astrup T, Epstein SE. The fibrinolytic response of man to vasoactive drugs measured in arterial blood. Thromb Res 1978; 13: 419-428
    CrossrefPubMedGoogle Scholar
  • 13 Szczeklik A, Kopec M, Sladek K, Musial J, Chmielewska J, Teisseyre E, Dudek-Wojciechowska G, Palester-Chlebowczyk M. Prostacyclin and the fibrinolytic system in ischemic vascular disease. Thromb Res 1983; 29: 655-660
    CrossrefPubMedGoogle Scholar
  • 14 Maier M, Starlinger M, Wagner M, Meyer D, Binder BR. The effect of hemorrhagic hypotension on urinary kallikrein excretion, renin activity, and renal cortical blood flow in the pig. Circ Res 1981; 48: 386-392
    CrossrefPubMedGoogle Scholar
  • 15 Smokovitis A. Regions of constantly increased plasminogen activator activity along the intima of the normal aorta. Haemostasis 1978; 7: 303-319
    PubMedGoogle Scholar
  • 16 Smokovitis A, Astrup T. Localization of fibrinolytic activity and inhibition of plasmin in the spinal cord of rat, guinea pig and rabbit. J Neurosurg 1978; 48: 1008-1014
    CrossrefPubMedGoogle Scholar
  • 17 Smokovitis A. Sex related fibrinolytic activity in rat tissues. Experientia 1978; 34: 483-484
    CrossrefPubMedGoogle Scholar
  • 18 Smokovitis A. Differences in tissue plasminogen activator activity and plasmin inhibition between newborn and adult rat. Haemostasis 1980; 9: 52-64
    PubMedGoogle Scholar
  • 19 Smokovitis A, Binder BR. The effect of the anabolic steroid stanozolol on tissue plasminogen activator activity and plasmin inhibition in the rat. Experientia 1980; 36: 1079-1080
    CrossrefPubMedGoogle Scholar
  • 20 Smokovitis A, Binder BR. Patterns of distribution of plasminogen activator and plasmin inhibitor in pig tissues. Pflügers Archiv, Eur J Physiol 1979; 379 (Suppl.): R 26
    PubMedGoogle Scholar
  • 21 Smokovitis A, Wagner M, Starlinger M, Opitz A, Binder BR. Fibrinolytische Aktivität im Gewebe bei experimenteller Hypovolämie. Kongreßbericht, 20 Tagung der Österreichischen Gesellschaft für Chirurgie, Demeter Verlag 1980; pp 853-855
    PubMedGoogle Scholar
  • 22 Anderson RJ, Taher MS, Cronin RE, McDonald KM, Schrier RW. Effect of beta-Adrenergic blockade and inhibitors of angiotensin II and prostaglandins on renal autoregulation. Am J Physiol 1975; 229: 731-736
    PubMedGoogle Scholar
  • 23 Freeman RH, Davis JO, Spielman WS, Lohmeier TE. High output heart failure in the dog: systemic and intrarenal role of angiotensin II. Am J Physiol 1975; 229: 474-478
    PubMedGoogle Scholar
  • 24 Kirschenbaum MA, White N, Stein JH, Ferris TF. Redistribution of renal cortical blood flow during inhibition of prostaglandin synthesis. Am J Physiol 1974; 227: 801-805
    PubMedGoogle Scholar
  • 25 Tysseboth I, Kirkeb A. The effect of indomethacin on renal blood flow distribution during hemodynamic hypotension in dog. Acta Physiol Scand 1977; 101: 15-21
    CrossrefPubMedGoogle Scholar
  • 26 Kwaan HC, McFadzeau AI S. On plasma fibrinolytic activity induced by ischemia. Clin Sci 1956; 15: 245
    PubMedGoogle Scholar
  • 27 Jakschik BA, Marshall GR, Kournik JL, Needleman P. Profile of circulating vasoactive substances in hemorrhagic shock and their pharmacologic manipulation. J Clin Invest 1974; 54: 842-852
    CrossrefPubMedGoogle Scholar
  • 28 Pullan PT, Johnston CI, Anderson WP, Korner PI. Plasma vasopressin in blood pressure homeostasis and in experimental renal hypertension. Am J Physiol 1980; 239: H81-H87
    PubMedGoogle Scholar