Patterns of vascular plasminogen activator activity (PAA) and of blood flow were compared
in the renal cortex of pigs. The comparison was made in pigs with or without induction
of hemorrhagic hypotension and continuous infusion of indomethacin (prostaglandin
synthetase inhibitor) or saralasin (competitive inhibitor of angiotensin II). Blood
flow was measured by radiolabelled microspheres. A significant decrease in the vascular
PAA was observed only in saralasin treated animals (15% in not hemorrhaged pigs and
30% in the inner and 45% in the outer half of the renal cortex in hemorrhaged pigs).
Changes in plasmin inhibitor activity in the renal cortex were not noted. No correlation
could be seen between vascular PAA and changes in blood flow in the renal cortex or
changes in the mean arterial blood pressure. The vascular fibrinolytic response to
saralasin should be due to an effect of saralasin independent of the changes in blood
flow induced by this agent.
Keywords
Blood flow - Renal cortex - Fibrinolysis - Indomethacin - Saralasin
