Incidence of Guillain–Barre's Syndrome in Children under 15 Years of Age in OmanFunding None.
21. Februar 2018
13. Mai 2018
19. Juni 2018 (online)
Objective Guillain–Barre's syndrome (GBS) is an acute immune-mediated polyradiculoneuropathy seen in all ages but mostly in the adult population. We aim to report the incidence of GBS in children under 15 years of age in Oman, a Gulf country.
Materials and Methods All children with GBS under 15 years of age were included in the study from January 2002 to December 2016. The data were compiled in Microsoft Excel format and analysis was performed using SPSS, version 17.0. Population-based age- and sex-specific rates of GBS were calculated using the estimated population for each 5-year period based on 2004, 2009, and 2014 mid-year population, respectively. Relative risk and 95% confidence intervals of GBS at different age categories were calculated using the overall incidence of GBS in those under 15 years as reference.
Results The average annual incidence in those under 15 years was 3.1/100,000. Age-specific incidence was 4.0/100,000 in the age group 0 to 9 years and 4.7/100,000 in age group 0 to 4 years. Sixty percent had evidence of preceding infections, and the male to female ratio was 1.8:1. Fifty percent had cranial nerve involvement and 18% needed mechanical ventilation. Five percent had residual weakness. Intravenous immunoglobulins (IVIGs) were used in all, and 3.3% required plasmapheresis when they did not improve with IVIG. Clinical profile of the GBS was not different from the rest reported in the literature.
Conclusion The incidence of GBS in Oman was 3.1/100,000 (range: 2.7–3.5 cases/100,000) in children under 15 years of age. The GBS is a smaller proportion among the total acute flaccid paralysis cases.
- 1 Koul R, Chacko A, Ahmed R, Varghese T, Javed H, Al-Lamki Z. Ten-year prospective study (clinical spectrum) of childhood Guillain-Barré syndrome in the Arabian peninsula: comparison of outcome in patients in the pre- and post-intravenous immunoglobulin eras. J Child Neurol 2003; 18 (11) 767-771
- 2 Hauck LJ, White C, Feasby TE, Zochodne DW, Svenson LW, Hill MD. Incidence of Guillain-Barré syndrome in Alberta, Canada: an administrative data study. J Neurol Neurosurg Psychiatry 2008; 79 (03) 318-320
- 3 Morris AM, Elliott EJ, D'Souza RM, Antony J, Kennett M, Longbottom H. Acute flaccid paralysis in Australian children. J Paediatr Child Health 2003; 39 (01) 22-26
- 4 Sejvar JJ, Baughman AL, Wise M, Morgan OW. Population incidence of Guillain-Barré syndrome: a systematic review and meta-analysis. Neuroepidemiology 2011; 36 (02) 123-133
- 5 Wu X, Shen D, Li T. , et al. Distinct clinical characteristics of pediatric Guillan Barre syndrome a comparative study between children and adults in Northeast China. PLoS One 2016; 11 (03) e0151611
- 6 Momen AA, Shakunia A. The epidemiology of Guillain Barre syndrome in children under 15 years old in southwest Iran. Biomed Hub 2017; 2 (03) 480693 . doi.org/10.1159/000480693
- 7 Islam Z, Jacobs BC, van Belkum A, Mohammad QD, Islam MB, Herbrink P, Diorditsa S, Luby SP, Talukder KA, Endtz HP. Axonal variant of Guillain-Barre syndrome associated with Campylobacter infection in Bangladesh. Neurology 2010; 74 (07) 581-587
- 8 Robertson SE, Suleiman AJ, Mehta FR, al-Dhahry SH, el-Bualy MS. Poliomyelitis in Oman: acute flaccid paralysis surveillance leading to early detection and rapid response to a type 3 outbreak. Bull World Health Organ 1994; 72 (06) 907-914
- 9 Fokke C, van den Berg B, Drenthen J, Walgaard C, van Doorn PA, Jacobs BC. Diagnosis of Guillain-Barré syndrome and validation of Brighton criteria. Brain 2014; 137 (Pt 1) 33-43
- 10 SPSS Inc. SPSS Statistics for Windows, Version 17.0. Chicago, IL: SPSS Inc;
- 11 Ministry of Health Oman, eHealth Portal. Annual Health Report 2016. Demographic features, Population characteristics; 2016-Chapter One. Available at: https://www.moh.gov.om/en/web/statistics/annual-reports . Accessed October 2017
- 12 Winner SJ, Evans JG. Age-specific incidence of Guillain-Barré syndrome in Oxfordshire. Q J Med 1990; 77 (284) 1297-1304
- 13 McGrogan A, Madle GC, Seaman HE, de Vries CS. The epidemiology of Guillain-Barré syndrome worldwide. A systematic literature review. Neuroepidemiology 2009; 32 (02) 150-163
- 14 Jasem J, Marof K, Nawar A. , et al. Guillain-Barré syndrome as a cause of acute flaccid paralysis in Iraqi children: a result of 15 years of nation-wide study. BMC Neurol 2013; 13: 195
- 15 Benamer HT, Bredan A. Guillain-Barré syndrome in Arab countries: a systematic review. J Neurol Sci 2014; 343 (1–2): 221-223
- 16 Hart DE, Rojas LA, Rosário JA, Recalde H, Román GC. Childhood Guillain-Barré syndrome in Paraguay, 1990 to 1991. Ann Neurol 1994; 36 (06) 859-863