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Hamostaseologie 1999; 19(01): 50-54
DOI: 10.1055/s-0038-1660377
Übersichtsarbeiten/Review Articles
Schattauer GmbH

Immunantwort auf rekombinantes Hirudin

Eine Übersicht
G. Huhle
1   I. Medizinische Klinik (Direktor: Prof D. L. Heene) Fakultät für Klinische Medizin Mannheim der Universität Heidelberg, Mannheim
,
Ursula Hoffmann
1   I. Medizinische Klinik (Direktor: Prof D. L. Heene) Fakultät für Klinische Medizin Mannheim der Universität Heidelberg, Mannheim
,
X. H. Song
1   I. Medizinische Klinik (Direktor: Prof D. L. Heene) Fakultät für Klinische Medizin Mannheim der Universität Heidelberg, Mannheim
,
D. L. Heene
1   I. Medizinische Klinik (Direktor: Prof D. L. Heene) Fakultät für Klinische Medizin Mannheim der Universität Heidelberg, Mannheim
,
J. Harenberg
1   I. Medizinische Klinik (Direktor: Prof D. L. Heene) Fakultät für Klinische Medizin Mannheim der Universität Heidelberg, Mannheim
› Author Affiliations
Further Information

Publication History

Publication Date:
27 June 2018 (online)

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Zusammenfassung

Rekombinantes Hirudin ist ein potentes, spezifisches Antithrombin-Agens, das in Hefezellen exprimiert wird. Die verschiedenen rekombinanten Hirudine befinden sich nun in der klinischen Prüfung bezüglich einer Anzahl von Indikationen. Die Ergebnisse vorliegender Studien versprechen eine hohe Effektivität und Sicherheit in der Vorbeugung von tiefen Beinvenenthrombosen und Lungenembolien bei Patienten mit elektiver Hüftchirurgie, bei Patienten mit akutem Myokardinfarkt, akutem koronaren Syndrom und der instabilen Angina mit nachfolgender Angioplastie. In diesen Studien waren unter der Therapie mit rekombinantem Hirudin allergische Reaktionen nicht aufgetreten. Rekombinantes Hirudin wurde ebenfalls hinsichtlich seiner Effektivität und Sicherheit bei Patienten mit heparin-induzierter Thrombozytopenie Typ II untersucht. Hier zeigte sich eine Inzidenz von Heparin-Antikörpern in bis zu 50% aller mit Hirudin langzeitbehandelten Patienten. Eine Immunantwort gegen rekombinantes Hirudin konnte ebenfalls in Tierversuchen zur Herstellung von monoklonalen Hirudinantikörpern produziert werden. Die vorliegenden Daten zeigen, daß die Hirudinantikörper teils hirudin-neutralisierende, teils halbwertszeitverlängernde Eigenschaften aufweisen. Die biologische Relevanz der Hirudin-Antikörper bleibt weiteren Studien vorbehalten.

Schlüsselwörter

Rekombinantes Hirudin - Antikörper - Allergie
 

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