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Hamostaseologie 1992; 12(01): 023-036
DOI: 10.1055/s-0038-1660310
DOI: 10.1055/s-0038-1660310
Übersichtsarbeit/Review Articles
Klinische Pharmakologie von Heparinen
Further Information
Publication History
Publication Date:
26 June 2018 (online)
Zusammenfassung
Ziel klinisch pharmakologischer Studien von Heparinen sind die Analysen der Bioverfügbarkeit und des Metabolismus. Die Untersuchungen erstrecken sich zum einen auf nicht modifizierte und zum anderen auf modifizierte Heparine und verwandte Substanzen. Neue Nachweisverfahren haben die Bedeutung der Hemmung der Faktor-Xa-Aktivität, des Feed-back loop und der Freisetzung des Extrinsic pathway inhibitor (jetzt: Tissue factor pathway inhibitor) herausgestellt. Untersuchungen zur Neutralisation mit Protaminchlorid legen eine Freisetzung von Mukopolysacchariden durch Heparine im Körper nahe. Chemische Modifikationen von Heparinen und verwandten Substanzen geben eine Aussicht auf bessere Nachweisverfahren, alternative Applikationsformen, spezifischere Wirkungen und neue Anwendungsgebiete.
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