Thrombogenese und Hämodynamik

L. J. Wurzinger

doi:10.1055/s-0038-1659923

Hämostaseologie, Table of Contents

Hamostaseologie 1988; 08(04): 173-182
DOI: 10.1055/s-0038-1659923

Originalarbeiten

Schattauer GmbH

Thrombogenese und Hämodynamik

Authors

L. J. Wurzinger

¹Anatomisches Institut der Technischen Universität München

Abstract

Zusammenfassung

Die in enger Kooperation von medizinisch-theoretischen (Anatomie, Physiologie) und ingenieurwissen-schaftlichen (Aerodynamisches Institut) Disziplinen an der RWTH Aachen erarbeiteten Befunde zeigen, daß nur jeweils ein verschwindend kleiner Anteil von Plättchen (und anderen Blutzellen) im alternden bzw. atherosklerotisch vorgeschädigten Kreislauf Bereiche kritischer Strömungskräfte durchläuft, von denen wiederum nur ein geringer Prozentsatz irreversibel geschädigt wird. Obwohl dieses Trauma grundsätzlich einen auslösenden Reiz auf das Hämo-stasesystem darstellt, erfordern die nachgeschalteten zellbiologischen und biochemischen Verstärkerschritte gänzlich andere fluiddynamische Bedingungen, als sie in schneller, ungestörter Rohrströmung gegeben sind. Die Manifestation und Lokalisation des Thrombus scheint von fluiddyna-misch abgeschlossenen Rezirkula-tionsgebieten bestimmt zu sein.

Full Text

References

Literatur
1 Colman R.W, Hirsh J, Marder V.J, Salzman E.W. (Eds) Hemostasis and Thrombosis. Philadelphia: Lippincott; 1982
2 Zwaal R.F.A, Comfurius P, van Deenen L.L.M. Membrane asymmetry and blood coagulation. Nature 1977; 268: 358.
3 Grette K. Studies on the mechanism of thrombin catalyzed hemostatic reactions in blood platelets. Acta Physiol Scand 1962; 56: 9.
4 Schmid-Schönbein H, Wurzinger L.J, Zimmermann R.E. (Eds) Enzyme Activation in Blood-Perfused Artificial Organs. Dordrecht: Martinus Nijhoff; 1985
5 Moneada S.R, Gryglewski R, Bunting S. et al. An enzyme isolated from arteries transforms prostaglandin endoperoxides to an unstable substance that inhibits platelet aggregation. Nature 1976; 263: 663.
6 Marlar R.A, Kleiss A.J, Griffin J.H. Mechanism of action of human activated protein C a thrombin-dependent anticoagulant enzyme. Blood 1982; 59: 1067-72.
7 Nerem R.M, Levesque M. Fluid dynamics as a factor in the localization of atherogene-sis. Ann NY Acad Sci 1983; 416: 709-17.
8 Murphy E.A, Rowsell H.C, Downie H.G. et al. Encrustation and atherosclerosis: the analogy between early in vivo lesions and deposits which occur in extracorporeal circulations. Canad Med Ass J 1962; 87: 259.
9 Hugh A.E, Fox A. The precise localization of atheroma and its association with stasis at the origin of the internal carotid artery – a radiographic investigation. Br J Radiol 1970; 43: 377.
10 Fry D.L. Hemodynamic forces in atheroge-nesis. In: Cerebral Vascular Diseases. Scheinberg P. (Ed) New York : Raven Press; 1976: 77.
11 Heliums J.D, Hardwick R.A. Response of platelets to shear stress – a review. In: Gross D.R, Hwang N.H.C. (Eds) The Rheology of Blood, Blood Vessels and Associated Tissues. Amsterdam : Sijhoff and Noordhoff; 1981: 160.
12 Holmsen H. Prostaglandin endoperoxide-thromboxane synthesis and dense granula secretion as positive feedback loops in the propagation of platelet responses during »the basic platelet reaction«. Thromb Haemostas 1977; 38: 1030-41.
13 Heuser G, Opitz R. A Couette viscometer for short time shearing of blood. Biorheology 1980; 17: 17.
14 Anderson G.H, Heliums J.D, Moake J.L. et al. Platelet lysis and aggregation in shear fields. Blood Cells 1978; 4: 499.
15 Stevens D.E, Joist J.H, Sutern S.P. Role of platelet-prostaglandin synthesis in shear-induced platelet alterations. Blood 1980; 56: 753-58.
16 Joist J.H, Baker R.K. Loss of ¹¹¹Indium as indicator of platelet injury. Blood 1981; 58: 350-3.
17 Petschek H.E, Adamis D, Kantrowitz A.R. Stagnation point flow thrombus formation. Trans Am Soc Artif Int Organs 1968; 14: 256-62.
18 Wurzinger L.J, Blasberg P, Horii F. et al. A stagnation point flow technique to measure platelet adhesion onto polymer films from native blood – a technical report. Thromb Res 1986; 44: 401-6.
19 Anderson G.H, Heliums J.D, Moake J.L. et al. Platelet response to shear stress: changes in serotonin uptake, serotinin release and ADP induced aggregation. Thromb Res. 1978; 13: 1039-47.
20 Zwaal R.F.A, Rosing J, Tans G. et al. Topological and kinetic aspects of phospholipids in blood coagulation. In: Mann K.G, Taylor F.B. (Eds) The Regulation of Coagulation. Amsterdam: Elsevier; 1980: 95.
21 Ugurbil K, Holmsen H, Shulman R.G. Adenine nucleotide storage and secretion in platelets as studied by ³¹P nuclear magnetic resonance. Proc Natl Acad Sci USA 1979; 75: 2227.
22 Wurzinger L.J, Opitz R, Wolf M. et al. Ultrastructural investigations on the question of mechanical activation of blood platelets. Blut 1987; 54: 97-107.
23 Turitto V.T, Baumgartner H.R. Platelet interaction with subendothelium in a perfusion system: physical role of red blood cells. Microvasc Res 1975; 9: 335.
24 Blasberg P, Wurzinger L.J, Schmid-Schönbein H. Microrheology of thrombocyte deposition: effect of stimulation, flow direction, and red cells. In: Schettler G, Nerem R.M, Schmid-Schönbein H, Morl H, Diehm C. (Eds) Fluid Dynamics as a Localizing Factor for Atherosclerosis. Heidelberg: Springer; 1983: 103.
25 Bergqvist D, Arfors K.E. Haemostatic platelet plug formation in the isolated rabbit mesenteric preparation – an analysis of red blood cell participation. Thromb Haemostas 1980; 44: 6-8.
26 Reimers R.C, Sutera S.P, Joist J.H. Potentiation by red blood cells of shear-induced platelet aggregation: relative importance of chemical and physical mechanisms. Blood 1984; 64: 1200-6.
27 Duhm J, Deuticke B, Gerlach E. 2,3-Di-phosphoglycerat – Stoffwechsel und Glukose in Menschen – Erythrozyten. Einfluß von Sulfat, Tetrathionat und Disulfit. Hoppe-Seyler’s Z Physiol Chem 1969; 350: 1008.
28 Baldauf W, Wurzinger L.J, Kinder J. The role of stagnation point flow in the formation of platelet thrombi on glass surfaces in tubes with various geometry. Path Res Pract 1978; 163: 9.
29 Nerem R.M, Rumberger J.A, Gross D.R. et al. Hot film coronary artery velocity measurements in horses. Cardiovasc Res 1974; 10: 301.
30 Caro C.G, Fitz-Gerald J.M, Schroter R.C. Atheroma and arterial wall shear: observation, correlation and proposal of a shear dependent mass transfer mechanism for atherogenesis. Proc Royal Soc London (Biol) 1971; 177: 109.
31 Karino T, Motomiya M. Flow visualization in isolated transparent natural blood vessels. Biorheology 1983; 20: 119.
32 Kratzer M.A.A, Kinder J. Streamline pattern and velocity components of flow in a model of a branching coronary vessel -possible functional implication for the development of localized platelet deposition in vitro. Microvasc Res 1986; 31: 250.
33 Mustard J.F, Packham M.A, Kinlough-Rathbone R.L. et al. Fibrinogen and ADP-induced platelet aggregation. Blood 1978; 52: 453-66.
34 Jaffe E.A, Leung L.L.K, Nachman R.L. et al. Thrombospondin is the endogenous lectin of human platelets. Nature 1982; 295: 246.
35 Koutts J, Walsh P.N, Plow E.F. et al. Active release of human platelet factor VHI-rela-ted antigen by adenosine diphosphate, collagen, and thrombin. J Clin Invest 1978; 62: 1255.
36 Wurzinger L.J, Blasberg P, Schmid-Schönbein H. Consolidation of platelet aggregates by fibrin despite heparin anticoagulation. Thromb Haemostas 1981; 46: 666.
37 Wurzinger L.J, Herbst K, Schmid-Schönbein H. Influence of platelet aggregate size and heparin concentration on thrombin. In: Breddin H.K, Bender N, Scharf R.E. (Eds). Recent Advances and New Developments in Haemostaseology. Haemostasis, 1986; 16 (Suppl. 05) 78-9.
38 Schmid-Schönbein H, Wurzinger L.J. Transport phenomena in pulsating poststenotic vortex flow in arteries – an interactive concept of fluid-dynamical, hemorheologi-cal, and biochemical processes in white thrombus formation. Nouv Rev Fr Hematol 1986; 28: 257-67.
39 Wurzinger L.J, Blasberg P, van de Loecht M. et al. Model experiments on platelet adhesion in stagnation point flow. Biorheology 1984; 21: 649.
40 Reiiiinger A. Platelet microthrombus formation on entothelial monolayers under stagnation point flow in vitro. Hämostasis 1988; 18 (Suppl. 02) 73.
41 Maino G, Shea S.M, Leventhal M. Endothelial contraction induced by histamine type mediators. J Cell Biol 1969; 42: 647.
42 Barnhart M.I, Chen S.T. Endothelial cell physiology, perturbations and responses. Sem Thromb Hemost 1978; 5: 60-86.
43 Sabbah H.N, Khaja F, Brymer J.F. et al. Blood flow in the coronary arteries of man: relation to atherosclerosis. In: Liepsch D. (Ed) Blood Flow in Large Arteries: Applications to Atherogenesis and Clinical Medicine. Basel: Karger; (im Druck).
44 Meyer J, Erbel R, Pop T. et al. PTCA und intrakoronare Lyse bei akutem Myokardinfarkt. Z Kardiol 1986; 75 (Suppl. 05) 83-91.