Download PDF
Thromb Haemost 1983; 49(03): 251
DOI: 10.1055/s-0038-1657378
Letter to the Editor
Schattauer GmbH Stuttgart

Protein C and the Development of Skin Necrosis During Anticoagulant Therapy

A W Broekmans
Haemostasis and Thrombosis Research Unit, Leiden University Hospital, Leiden, The Netherlands
,
R M Bertina
Haemostasis and Thrombosis Research Unit, Leiden University Hospital, Leiden, The Netherlands
,
E A Loeliger
Haemostasis and Thrombosis Research Unit, Leiden University Hospital, Leiden, The Netherlands
,
V Hofmann
1   Department of Internal Medicine, University Hospital Zürich, Switzerland
,
H-G Klingemann
2   The Department of Internal Medicine, University Hospital, Marburg, West-Germany
› Author Affiliations
Further Information

Publication History

Received 25 March 1983

Accepted 25 April 1983

Publication Date:
18 July 2018 (online)

  PDF Download  Permissions and Reprints
 

  • References

  • 1 Van Amstel WJ, Boekhout-Mussert MJ, Loeliger EA. Successful prevention of coumarin-induced hemorrhagic skin necrosis by timely administration of vitamin Kj. Blut 1978; 36: 89-93
    CrossrefPubMedGoogle Scholar
  • 2 Boss JM, Summerly R. Prevention of warfarin-induced skin necrosis. Br J Dermatol 1979; 100: 617
    CrossrefPubMedGoogle Scholar
  • 3 Hoffmann V, Frick PG. Repeated occurrence of skin necrosis twice following coumarin intake and subsequently during decrease of vitamin K dependent coagulation factors associated with cholestasis. Thromb Haemostas 1982; 48: 245-246
    PubMedGoogle Scholar
  • 4 Stenflo J. A new vitamin K dependent prote. purification from bovine plasma and preliminary characterization. J Biol Chem 1976; 251: 355-363
    PubMedGoogle Scholar
  • 5 Nesheim ME, Canfield WM, Kisiel W, Mann KG. Studies of the capacity of factor Xa to protect factor Va from inactivation by activated protein C. J Biol Chem 1982; 257: 1443-1447
    PubMedGoogle Scholar
  • 6 Marlar RA, Kleiss AJ, Griffin JH. Human protein C: inactivation of factor V and VIII in plasma by the activated molecule. Ann NY Acad Sci 1981; 370: 303-310
    CrossrefPubMedGoogle Scholar
  • 7 Comp PC, Esmon CT. Generation of fibrinolytic activity by infusion of activated protein C into dogs. J Clin Invest 1981; 68: 1221-1228
    CrossrefPubMedGoogle Scholar
  • 8 Griffin JH, Evatt B, Zimmerman TS, Kleiss AJ, Wideman C. Deficiency of protein C in congenital thrombotic disease. J Clin Invest 1980; 68: 1370-1373
    PubMedGoogle Scholar
  • 9 Bertina RM, Broekmans AW, Van der Linden IK, Mertens K. Protein C deficiency in a Dutch family with thrombotic disease. Thromb Haemostas 1982; 48: 1-5
    PubMedGoogle Scholar
  • 10 Klingemann H-G, Egbring R. Die Kumarinnekrose. Med Welt 1982; 33: 676-677
    PubMedGoogle Scholar
  • 11 Owen WG. The control of haemostasis; role of endothelium in the regulation of inhibitory and catabolic pathways. Arch Pathol Lab Med 1982; 106: 209-213
    PubMedGoogle Scholar