Summary
The clearance of radiolabeled human fibrinogen fragments X and Y was studied in the mouse model. Fragment X cleared rapidly from the circulation with less than 10% of the ligand remaining in the circulation at 4 hr. The clearance of fragment Y was somewhat slower, but was identical to the rate of clearance of fragment D,. Competition studies indicated that fragments X, Y, D, and D! dimer clear via the same, saturable pathway. Fragment E did not compete for the clearance of these ligands. Tissue distribution studies demonstrated that the liver was the principal site of clearance of all three ligands. The kidneys also cleared a fraction of each ligand in the order fragment D3>D2>D1 >Y>X. This pattern suggests that renal clearance is a passive phenomenon dependent on the size of the fibrinogen degradation product.
Keywords
Fibrinogen fragments - Plasma clearance