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Thromb Haemost 1983; 49(01): 028-031
DOI: 10.1055/s-0038-1657309
Original Article
Schattauer GmbH Stuttgart

Intracoronary Platelet Release in Patients with and without Coronary Artery Disease

F W Verheugt
The Thoraxcenter and Department of Haematology, Dijkzigt Hospital, Erasmus University, Rotterdam, The Netherlands
,
P W Serruys
The Thoraxcenter and Department of Haematology, Dijkzigt Hospital, Erasmus University, Rotterdam, The Netherlands
,
H van Vliet
The Thoraxcenter and Department of Haematology, Dijkzigt Hospital, Erasmus University, Rotterdam, The Netherlands
,
A Spijkers
The Thoraxcenter and Department of Haematology, Dijkzigt Hospital, Erasmus University, Rotterdam, The Netherlands
,
P G Hugenholtz
The Thoraxcenter and Department of Haematology, Dijkzigt Hospital, Erasmus University, Rotterdam, The Netherlands
› Author Affiliations
Further Information

Publication History

Received 20 July 1982

Accepted 08 December 1982

Publication Date:
18 July 2018 (online)

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Summary

Intracoronary platelet release of beta-thromboglobulin (BTG) was measured in 18 patients with a history of chest pain by analysis of aortic and coronary sinus blood samples in rest and during atrial pacing. Eleven proved to have coronary artery disease, while seven had normal coronary arteriograms and served as controls. In both groups no statistically significant transmyocardial gradient of platelet and plasma BTG content was observed under basal conditions, although the aortic plasma BTG levels in the patients (60.4 ± 4.1 ng/ml) were significantly (p <0.05) higher than in the controls (47.5 ± 2.6 ng/ml). However, also during atrial pacing no significant gradient could be demonstrated in the patients nor in the controls. It is concluded, that in stable coronary artery disease measurable intracoronary platelet release does not occur in rest nor atrial pacing and, therefore, does not seem to contribute to the development of exercise-induced myocardial ischaemia.

Keywords

Coronary artery disease - Angina pectoris - Platelet release - Beta - thromboglobulin
 

  • References

  • 1 Ross R, Glomset J, Kariya B. A platelet dependent serum factor that stimulates the proliferation of arterial smooth muscle cells in vitro. Proc Natl Acad Sci USA 1974; 71: 1207-1210
    CrossrefPubMedGoogle Scholar
  • 2 Griepp RB, Stinson EB, Bieber CP, Reitz BA, Copeland JG, Oyer PE, Shumway NE. Control of graft arteriosclerosis in human heart transplantation. Surgery 1977; 81: 262-269
    PubMedGoogle Scholar
  • 3 Pick R, Chediak J, Glick G. Aspirin inhibits development of coronary atherosclerosis in cynomolgus monkeys fed an atherogenic diet. J Clin Invest 1979; 63: 158-162
    CrossrefPubMedGoogle Scholar
  • 4 Haerem JW. Platelet aggregates in intramyocardial vessels of patients dying suddenly and unexpectedly of coronary artery disease. Atherosclerosis 1972; 15: 199-213
    CrossrefPubMedGoogle Scholar
  • 5 Anturane Reinfarction Trial Research Group. Sulfinpyrazone in the prevention of cardiac death after myocardial infarction: The Anturane Reinfarction Trial. N Engl J Med 1978; 298: 289-295
    CrossrefPubMedGoogle Scholar
  • 6 Green HG, Seroppian E, Handin RI. Platelet activation during exercise-induced myocardial ischemia. N Engl J Med 1980; 302: 193-197
    CrossrefPubMedGoogle Scholar
  • 7 Schafer AI, Handin RI. The role of platelets in thrombotic and vascular disease. Prog Cardiovasc Dis 1979; 22: 31-52
    CrossrefPubMedGoogle Scholar
  • 8 Boer AC De, Turpie AG G, Butt R, Genton E. Thromboxane B2 and betathromboglobulin in symptomatic coronary artery disease. Thromb Haemostas 1981; 46: 268 (Abstr.)
    PubMedGoogle Scholar
  • 9 Mehta J, Mehta P, Conti CR. Platelet function studies in coronary heart disease: IX. Increased platelet prostaglandin generation and abnormal platelet sensitivity to prostacyclin and endoperoxide analog in angina pectoris. Am J Cardiol 1980; 46: 943-947
    CrossrefPubMedGoogle Scholar
  • 10 Hirsh PD, Hillis LD, Campbell WB, Firth BG, Willerson JT. Release of prostaglandins and thromboxane into the coronary circulation in patients with ischemic heart disease. N Engl J Med 1981; 304: 685-691
    CrossrefPubMedGoogle Scholar
  • 11 Malpass TW, Ritchie JL, Harker LA. Platelet alpha-granule release in survivors of out-of-hospital ventricular fibrillation and patients with symptomatic coronary artery disease. Circulation 1980; 62 suppl (03) 385
    PubMedGoogle Scholar
  • 12 Mehta J, Mehta P, Pepine CJ. Platelet aggregation in aortic and coronary venous blood in patients with and without coronary disease. Circulation 1978; 58: 881-886
    CrossrefPubMedGoogle Scholar
  • 13 Mehta J, Mehta P, Pepine CJ, Conti CR. Platelet function studies in coronary artery disease: VII. Effect of aspirin and tachycardia on aortic and coronary venous blood. Am J Cardiol 1980; 45: 945-951
    CrossrefPubMedGoogle Scholar
  • 14 Kuzuya T, Tada M, Inoue M, Kodama M, Takeda M, Mishima M, Inui M, Abe M. Increased levels of thromboxane A2 in peripheral and coronary circulation in patients with angina pectoris. Am J Cardiol 1980; 45: 454
    PubMedGoogle Scholar
  • 15 Lewy RI, Wiener L, Walinsky P, Lefer AM, Silver MJ, Smith JB. Thromboxane release during pacing induced angina: possible vasoconstrictor influence on the coronary vasculature. Circulation 1980; 61: 1165-1171
    CrossrefPubMedGoogle Scholar
  • 16 Rubinstein MD, Baim DS, Wall RT, Harrison DC. Increased platelet activity in the human coronary circulation in coronary atherosclerosis and spasm. Circulation 1980; 62 suppl (03) 276
    PubMedGoogle Scholar
  • 17 Simoons ML, Hugenholtz PG. Estimation of the probability of exercise-induced ischaemia by quantitative ECG analysis. Circulation 1977; 56: 552-559
    CrossrefPubMedGoogle Scholar
  • 18 Remme WJ, De JongJ W, Verdouw PD. Effects of pacing-induced myocardial ischemia on hypoxanthine efflux from the human heart. Am J Cardiol 1977; 40: 55-63
    CrossrefPubMedGoogle Scholar
  • 19 Chierchia S, Caterina RDe, Brunelli C, Crea F, Patrono C, Maseri A. Low-dose aspirin prevents thromboxane A2 synthesis by platelets, but not attacks of Prinzmetal angina. Circulation 1980; 62 suppl (03) 215
    PubMedGoogle Scholar
  • 20 Serruys PW, Steward R, Booman F, Michels R, Reiber J HC, Hugenholtz PG. Can unstable angina pectoris be due to increased coronary vasomotor tone?. Eur Heart J 1980; 01: 71-85
    CrossrefPubMedGoogle Scholar
  • 21 Frishman WH, Christodolou J, Weksler B, Smithen C, Killip T, Scheidt S. Aspirin therapy in angina pectoris: effects on platelet aggregation, exercise tolerance and electrocardiographic manifestations of ischaemia. Am Heart J 1976; 92: 03-10
    CrossrefPubMedGoogle Scholar
  • 22 Steele P, Rainwater J, Vogel R. Abnormal platelet survival time in men with myocardial infarction and normal coronary arteriogram. Am J Cardiol 1978; 41: 60-62
    CrossrefPubMedGoogle Scholar
  • 23 Chierchia S, Crea F, Bernini W, Caterina R De, Maseri A. Effects of continuous prostacyclin (PGI2) infusion in angina at rest. Circulation 1980; 62 suppl (03) 310
    PubMedGoogle Scholar
  • 24 Robertson RM, Robertson D, Roberts LJ, Maas RL, FitzGerald GA, Friesinger GC, Oates JA. Thromboxane A2 in vasotonic angina pectoris. N Engl J Med 1981; 304: 998-1003
    CrossrefPubMedGoogle Scholar
  • 25 Miwa K, Kambara H, Kawai C. Exercise-induced angina provoked by aspirin administration in patients with variant angina. Am J Cardiol 1981; 47: 1210-1214
    CrossrefPubMedGoogle Scholar
  • 26 Sobel M, Salman EW, Davies GC, Handin RI, Sweeney J, Ploetz J, Kurland G. Circulating platelet products in unstable angina pectoris. Circulation 1981; 63: 300-306
    CrossrefPubMedGoogle Scholar
  • 27 Mathis PC, Wohl H, Wallach SR, Engler RL. Lack of release of platelet factor 4 during exercise induced myocardial ischemia. N Engl J Med 1981; 304: 1275-1278
    CrossrefPubMedGoogle Scholar
  • 28 Dalai JJ, Sheridan DJ, Bloom AL, Henderson AH. Platelet aggregates and coronary spasm. Lancet 1980; 02: 1146-1147
    PubMedGoogle Scholar
  • 29 Doyle DJ, Chesterman CN, Cade JP, McGready JR, Rennie CG, Morgan FJ. Plasma concentration of platelet-specific proteins correlated with platelet survival. Blood 1980; 55: 82-84
    PubMedGoogle Scholar
  • 30 Mehta P, Mehta J. Exercise platelet-activated myocardial ischemia in coronary artery disease. Am Heart J 1982; 103: 49-53
    CrossrefPubMedGoogle Scholar
  • 31 Steele PP. Platelet suppressants inhibit release of beta-thromboglobulin during isometric exercise in coronary disease. Clin Res 1979; 28: 214
    PubMedGoogle Scholar
  • 32 Green D, Santhanam S, Krumlowsky FA, Delgreco F. Elevated beta-thromboglobulin levels in patients with renal failure: effects of haemodialysis. J Lab Clin Med 1979; 95: 679-685
    PubMedGoogle Scholar
  • 33 Duncan A. Beta-thromboglobulin levels and oral contraception. Lancet 1979; 02: 631
    PubMedGoogle Scholar
  • 34 Schernthaner G, Muehlhauser I, Silberbauer K. Beta-thromboglobulin lowered by dipyridamole in diabetes. Lancet 1979; 02: 748
    PubMedGoogle Scholar
  • 35 Matthew JH, O’Connor JF, Heamshaw JR, Wood JK. Beta-thromboglobulin and glycosylated haemoglobin in diabetes mellitus. Scand J Haematol 1979; 05: 421-426
    PubMedGoogle Scholar
  • 36 Schernthaner G, Ludwig M, Silberbauer K. Elevated beta-thromboglobulin levels in multiple myeloma and in polycythaemia vera. Act Haematol 1979; 62: 219-222
    PubMedGoogle Scholar
  • 37 Adler AJ, Lundin AP, Feimoth MV, Friedman EA, Berlyne GM. Beta-thromboglobulin levels in the nephrotic syndrome. Am J Med 1980; 69: 551-554
    CrossrefPubMedGoogle Scholar
  • 38 Nenci GG, Berreti M, Todisco T, Pariso P. Enhanced beta-thromboglobulin in hypoxemia: effect of dipyridamole. N Engl J Med 1981; 204: 1044
    PubMedGoogle Scholar
  • 39 Dorsch C, Meyerhoff J. Elevated plasma beta-thromboglobulin levels in systemic lupus erythematosis. Thromb Res 1980; 20: 617-622
    CrossrefPubMedGoogle Scholar
  • 40 Duncan A, Depratti VJ, George RR. Elevated beta-thromboglobulin levels associated with smoking and oral contraceptive agents in normal healthy women. Thromb Res 1981; 21: 425-430
    CrossrefPubMedGoogle Scholar
  • 41 Smitherman TC, Milam M, Woo J, Willerson JT, Frenkel EP. Elevated beta-thromboglobulin in peripheral venous blood in patients with acute myocardial ischemia: direct evidence for enhanced platelet activity in vivo. Am J Cardiol 1981; 48: 395-402
    CrossrefPubMedGoogle Scholar