Effects of Cigarette Smoking on the Ultrastructure of Rat Thoracic Aorta and Its Ability to Produce Prostacyclin

R M Pittilo; I J Mackie; P M Rowles; S J Machin; N Woolf

doi:10.1055/s-0038-1657250

Thrombosis and Haemostasis, Inhaltsverzeichnis

Thromb Haemost 1982; 48(02): 173-176
DOI: 10.1055/s-0038-1657250

Original Article

Schattauer GmbH Stuttgart

Effects of Cigarette Smoking on the Ultrastructure of Rat Thoracic Aorta and Its Ability to Produce Prostacyclin

R M Pittilo

The Departments of Histopathology and Haematology, The Middlesex Hospital Medical School, London, U. K.

,

I J Mackie

The Departments of Histopathology and Haematology, The Middlesex Hospital Medical School, London, U. K.

,

P M Rowles

The Departments of Histopathology and Haematology, The Middlesex Hospital Medical School, London, U. K.

,

S J Machin

The Departments of Histopathology and Haematology, The Middlesex Hospital Medical School, London, U. K.

,

N Woolf

The Departments of Histopathology and Haematology, The Middlesex Hospital Medical School, London, U. K.

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Abstract

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Summary

Following exposure of rats to graded doses of fresh cigarette smoke, the aortic endothelium examined by scanning electron microscopy regularly showed alterations. These essentially consisted of areas of blebbing and microvillus-like projections from the luminal surface, and the presence in the majority of cases, of micro-thrombi in the low shear areas just proximal to intercostal branches. Aortas from rats exposed to smoke showed a reduction in prostacyclin production in vitro and platelets from these animals aggregated more readily than did those of controls.

Keywords

Cigarette smoking - Endothelial ultrastructure - Prostacyclin - Platelet aggregation

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Referenzen

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