Summary
14 patients with myeloproliferative diseases (MD) showed low 5-hydroxytryptamine (5-HT)
platelet content and high beta-thromboglobulin (β-TG) plasma levels.
This pattern could support the view that MD platelets undergo “in vivo“ degranulation.
A single dose of aspirin was unable to induce modification of platelet 5-HT and plasma
β-TG, whereas 6 out of 14 patients
No modification of platelet 5-HT was obtained suggesting that the cause of dense bodies
deficiency may lie in the production of abnormal platelets and not be related to “in
vivo” degranulation.
Keywords
Platelets - Myeloproliferative diseases - Beta-thromboglobulin - 5-hydroxytryptamine
- Aspirin
