Summary
Platelet aggregation was studied in 24 patients in the chronic stage of ischemic cerebrovascular
disease (CVD), with cerebral affluent and effluent blood, i.e., carotid arterial and
internal jugular venous blood, and also with peripheral venous blood. Aggregation
tests were performed at various final concentrations of sodium arachidonate (A.A.)
and ADP. In 17 patients, not taking aspirin, platelet aggregability in jugular venous
blood was significantly accentuated compared with that in arterial and peripheral
venous blood. This tendency was more marked in the patients with cerebral artery stenosis
and/or occlusion than in those with normal cerebral angiogram. In 7 patients taking
500 mg or more oral aspirin, aggregation differences across the brain were not observed
and A.A. aggregation and the second phase of ADP aggregation were completely suppressed.
These results suggest that a prophylactic administration of aspirin may be beneficial
for patients in chronic stage of CVD.
Keywords
Platelet aggregation - Ischemic cerebrovascular disease - Cerebral affluent and effluent
blood - Aspirin
