Thrombin Inhibition and Thrombin Generation by Cultured Aortic Endothelial and Smooth Muscle Cells from Minipig

B Kirchhof; J Grünwald

doi:10.1055/s-0038-1657227

Thrombosis and Haemostasis, Inhaltsverzeichnis

Thromb Haemost 1982; 48(01): 101-103
DOI: 10.1055/s-0038-1657227

Original Article

Schattauer GmbH Stuttgart

Thrombin Inhibition and Thrombin Generation by Cultured Aortic Endothelial and Smooth Muscle Cells from Minipig

Autor*innen

B Kirchhof

¹The Department of Internal Medicine, University of Münster, Federal Republic of Germany
J Grünwald

²The institute for Arteriosclerosis Research at the University of Münster, Münster, Federal Republic of Germany

Abstract

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Summary

Endothelial and smooth muscle cells cultured from minipig aorta were examined for their inhibitory activity on thrombin and for their thrombin generating capacity.

Endothelial cells showed both a thrombin inhibition and an activation of prothrombin in the presence of Ca⁺⁺, which was enhanced in the presence of phospholipids. Smooth muscle cells showed an activation of prothrombin but at a lower rate. Both coagulation and amidolytic micro-assays were suitable for studying the thrombin-vessel wall interaction.

Keywords

Thrombin generation - Thrombin inhibition - Endothelial cells - Smooth muscle cells

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Referenzen

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