Synthesis of Thromboplastin Protein by a Murine Macrophage-Like Cell Line

Summary

The established murine macrophage cell line J-774.1 responds to endotoxin with synthesis of thromboplastin apoprotein. The response develops in the absence of added lymphocytes and there is no increased responsiveness in cocultures of J-774.1 cells and BALB/c lymphocytes. J-774.1 cells therefore do not depend on lymphocyte cooperation for their response to endotoxin.

Key words

Endotoxin - J-774.1 cells - Lymphocytes - Thromboplastin - TPA

• References

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