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Thromb Haemost 1982; 47(02): 128-131
DOI: 10.1055/s-0038-1657146
Original Article
Schattauer GmbH Stuttgart

Partial Characterization of a Fibrinolytic Inhibitor Produced by Cultured Endothelial Cells Derived from Human Umbilical Vein

F Esnard
The Laboratory of Biochemistry, Faculty of Medicine, Tours, France, and from INSERM Unit 150, Hôpital Lariboisière, Paris, France
,
E Dupuy
The Laboratory of Biochemistry, Faculty of Medicine, Tours, France, and from INSERM Unit 150, Hôpital Lariboisière, Paris, France
,
A M Dosne
The Laboratory of Biochemistry, Faculty of Medicine, Tours, France, and from INSERM Unit 150, Hôpital Lariboisière, Paris, France
,
E Bodevin
The Laboratory of Biochemistry, Faculty of Medicine, Tours, France, and from INSERM Unit 150, Hôpital Lariboisière, Paris, France
› Author Affiliations
Further Information

Publication History

Received 26 October 1981

Accepted 08 February 1982

Publication Date:
13 July 2018 (online)

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Summary

A preliminary characterization of a fibrinolytic inhibitor released by human umbilical vein endothelial cells in primary culture is reported. This molecule of Mr comprised between 2 × 105 and 106 and of μ2 mobility precipitates at 43% ammonium sulphate saturation and is totally adsorbed on Concanavalin A Sepharose 4 B. A possible relationship with a macroglobulins is discussed.

Key words

Fibrinolysis inhibition - Urokinase - Endothelial cells - Umbilical vein
 

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