Thromb Haemost 1982; 47(01): 66-68
DOI: 10.1055/s-0038-1657128
Original Article
Schattauer GmbH Stuttgart

Successive Factor VIII Doses for a Haemophiliac Undergoing Major Surgery Calculated on a Microcomputer

Bruce Duncan
The Haematology Division, Institute of Medical and Veterinary Science, Adelaide, South Australia
,
John Lloyd
The Haematology Division, Institute of Medical and Veterinary Science, Adelaide, South Australia
,
Elizabeth Lesnikowski
The Haematology Division, Institute of Medical and Veterinary Science, Adelaide, South Australia
› Author Affiliations
Further Information

Publication History

Received 25 May 1981

Accepted 05 January 1982

Publication Date:
13 July 2018 (online)

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Summary

Doses of factor VIII to be infused into a haemophiliac undergoing major surgery were calculated on a micro-computer. The degree to which the particular patient responded to infused factor VIII and the rate at which it decayed were estimated by two pre-operative experiments. Plasma levels of factor VIII were predicted over fourteen days during which time the patient was infused with 53,000 iu. A continuous plot of predicted values with time was displayed on a video monitor. The predicted values showed good agreement with assay results.