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Thromb Haemost 1979; 42(05): 1411-1416
DOI: 10.1055/s-0038-1657040
Original Article
Schattauer GmbH Stuttgart

Isolation of Peptides with Anti-Urokinase Activity from the Human Placenta

Mieczyslaw Uszynski
The Institute of Obstetrics and Gynaecology, the Medical Academy, Lódź and the Department of Obstetrics and Gynaecology, the Joint County Hospital, Wloclawek, Poland
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Further Information

Publication History

Received 23 March 1979

Accepted 16 August 1979

Publication Date:
23 August 2018 (online)

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Summary

It is known that the fibrinolysis inhibitors in the human placenta are proteins which, in vitro, block urokinase plasminogen activation and are for this reason called urokinase inhibitors. In the present study it was found, for the first time, that a low-molecular urokinase inhibitor also occurs in the human placenta. It is a peptide which can be isolated through a three-step procedure: dialysis of human placenta homogenate, extraction of peptides from a filtrable fraction, and ion exchange chromatography of peptides on a Dowex-50 column.

 

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