Heparin, Protamine and Polybrene

Anthony Britten

doi:10.1055/s-0038-1656300

Thrombosis and Haemostasis, Table of Contents

Thromb Haemost 1965; 13(02): 550-560
DOI: 10.1055/s-0038-1656300

Originalarbeiten — Original Articles — Travaux Originaux

Schattauer GmbH

Heparin, Protamine and Polybrene

Their Effect upon Certain Coagulation Factors after Incubation with Plasma

Anthony Britten M. B., B. Ch.

¹ Blood Bank and Transfusion Service, Massachusetts General Hospital, Boston, Mass., U.S.A.

› Author Affiliations

Abstract

Summary

The effects of incubating heparin, protamine or Polybrene with plasma were studied. All three drugs cause rapid loss of factor V from decalcified plasma, while Polybrene also accelerates the loss of factor VIII activity. These changes are related to temperature, the period of incubation and the dose of the drug used, and can be partially prevented by inclusion of neutralizing doses of the appropriate antagonist in the incubation mixture.

The implications of these findings are discussed.

Full Text

References

References
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