Haemoglobinaemia and Haemoglobinuria Following the Administration of Neodymium 3-Sulpho-Isonicotinate (Thrombodym)

Summary

Nine of thirteen patients receiving daily intravenous injections of 375 mg. 3-sulpho-isonicotinate for four to eight days developed haemoglobinaemia, accompanied in one case by haemoglobinuria and methaemalbuminaemia. In addition to haemoglobinaemia, a rise in blood cholesterol was observed in rabbits given larger doses.

• References

• 1 Beaser S. B, Segel A, and Leroy V. The anticoagulant effects in rabbits and man of the intravenous injection of salts of the rare earth metals. J. clin. Invest. 21: 4 447 1942;
• 2 Hartenbach W. Über die praktische Bedeutung der gebräuchlichsten Antikoagulantia in der Chirurgie. Münch, med. Wschr. 97: 14 423 1955;
• 3 Hunter R. B, and Walker W. Neodymium 3-sulpho-isonicotinate and blood coagulation. Brit. med. J. 2: 1214 1956;
• 4 Thiess H, and Boecker D. Klinische Erfahrungen mit einem neuen Antithrombotikum aus der Gruppe der seltenen Erden. Dtsch. med. Wschr. 78: 222 1953;
• 5 Vincke E. Letter in Brit. med. J. 1: 882 1957;
• 6 Wilbrand U. Klinische Erfahrungen mit dem neuen Antithrombotikum „Thrombodym“. Dtsch. med. Wschr. 78: 330 1953;