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Thromb Haemost 1997; 77(06): 1052-1054
DOI: 10.1055/s-0038-1656110
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Factor V Leiden, C>T MTHFR Polymorphism and Genetic Susceptibility to Preeclampsia

Elvira Grandone
Arteriosclerosis and Thrombosis Unit and Division of Obstetrics and Gynecology, I.R.C.C.S. "Casa Sollievo della Sofferenza", S.Giovanni R. (FG), University of Palermo, Italy
,
Maurizio Margaglione
Arteriosclerosis and Thrombosis Unit and Division of Obstetrics and Gynecology, I.R.C.C.S. "Casa Sollievo della Sofferenza", S.Giovanni R. (FG), University of Palermo, Italy
,
Donatella Colaizzo
Arteriosclerosis and Thrombosis Unit and Division of Obstetrics and Gynecology, I.R.C.C.S. "Casa Sollievo della Sofferenza", S.Giovanni R. (FG), University of Palermo, Italy
,
Giuseppe Cappucci
Arteriosclerosis and Thrombosis Unit and Division of Obstetrics and Gynecology, I.R.C.C.S. "Casa Sollievo della Sofferenza", S.Giovanni R. (FG), University of Palermo, Italy
,
Dario Paladini
1   Department of Obstetrics and Gynecology, University "Federico II", Naples, University of Palermo, Italy
,
Pasquale Martinelli
1   Department of Obstetrics and Gynecology, University "Federico II", Naples, University of Palermo, Italy
,
Sergio Montanaro
Arteriosclerosis and Thrombosis Unit and Division of Obstetrics and Gynecology, I.R.C.C.S. "Casa Sollievo della Sofferenza", S.Giovanni R. (FG), University of Palermo, Italy
,
G Pavone
Arteriosclerosis and Thrombosis Unit and Division of Obstetrics and Gynecology, I.R.C.C.S. "Casa Sollievo della Sofferenza", S.Giovanni R. (FG), University of Palermo, Italy
,
Giovanni Di Minno
2   Institute of Internal Medicine and Geriatrics, University of Palermo, Italy
› Author Affiliations
Further Information

Publication History

Received 07 February 1997

Accepted after revision 08 April 1997

Publication Date:
12 July 2018 (online)

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Summary

We performed a case-controlled study to investigate whether the FV Leiden mutation and the C>T677 polymorphism of the 5,10 methylene tetrahydrofolate reductase (MTHFR) are associated with the occurrence of preeclampsia in 96 otherwise healthy preeclamptic women and 129 parous women as controls. FV Leiden carriers were 10 (10.5%) in cases and 3 (2.3%) in controls (OR: 4.9, 95% Cl: 1.3-18.3). MTHFR TT homozygotes were 28 (29.8%) in cases and 24 (18.6%) in the control group (OR: 1.8,95% Cl 1.0-3.5). No difference in any of the polymorphisms was found between proteinuric (n = 45) and non-proteinur-ic (n = 51) patients. Moreover, MTHFR polymorphism does not affect the association between FV Leiden and preeclampsia. In conclusion, FV Leiden mutation and MTHFR TT genotype are associated with the occurrence of preeclampsia, suggesting that, during pregnancy, women carrying these gene variants are prone to develop such a complication.

 

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