Plasminogen Activation by Invasive Human Pathogens^[*]

Summary

In this review the interaction between invasive human pathogens expressing plasmin(ogen) receptors and/or producing plasminogen activators with the human plasmin(ogen) system is described. Evidence is presented for multiple mechanisms by which human pathogens can acquire a surface bound form of plasmin that cannot be regulated by host serpins. The potential importance of these pathways in providing the organisms with the ability to cross tissue barriers is discussed.

Compiled from references 16,57-68.1. This work was supported in part by grant #HL41898 from the National Institutes of Health

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