Thromb Haemost 1997; 77(01): 001-010
DOI: 10.1055/s-0038-1655727
Review Article
Schattauer GmbH Stuttgart

Plasminogen Activation by Invasive Human Pathogens[*]

Michael D P Boyle
1   The Department of Microbiology, Medical College of Ohio, Toledo, Ohio, College of Medicine, Gainesville, Florida, USA
,
Richard Lottenberg
2   The Division of Hematology/Oncology, Department of Medicine, University of Florida, College of Medicine, Gainesville, Florida, USA
› Author Affiliations
Further Information

Publication History

Received 08 July 1996

Accepted after revision 08 October 1996

Publication Date:
11 July 2018 (online)

Summary

In this review the interaction between invasive human pathogens expressing plasmin(ogen) receptors and/or producing plasminogen activators with the human plasmin(ogen) system is described. Evidence is presented for multiple mechanisms by which human pathogens can acquire a surface bound form of plasmin that cannot be regulated by host serpins. The potential importance of these pathways in providing the organisms with the ability to cross tissue barriers is discussed.

Compiled from references 16,57-68.1. This work was supported in part by grant #HL41898 from the National Institutes of Health


 
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