Summary
The glycolytic enzyme poisons potassium cyanide, sodium fluoride, and monofluoroacetate
do not inhibit platelet clumping. The sulphydryl inhibitors, n-ethyl maleimide and
p-hydroxymercuribenzoate, inhibit platelet aggregation produced by ADP, ATP, nor-adrenaline,
5HT, thrombin and connective tissue extract. This inhibitory activity is counteracted
by 1-cysteine. These results suggest that platelet thiol groups are involved in the
platelet adhesion occurring during aggregation.