Thrombosis and Haemostasis, Table of Contents Thromb Haemost 1962; 07(02): 273-279DOI: 10.1055/s-0038-1655475 Originalarbeiten — Original Articles — Travaux Originaux Schattauer GmbH Clot Component Reacting with Thrombin[*] Hugon Kowarzyk 1 Ludwik Hirszfeld Institute of Immunology and Experimental Therapy, Polish Academy of Sciences, Wrocław , Irena Głogowska 1 Ludwik Hirszfeld Institute of Immunology and Experimental Therapy, Polish Academy of Sciences, Wrocław , Stanisław Szymik 1 Ludwik Hirszfeld Institute of Immunology and Experimental Therapy, Polish Academy of Sciences, Wrocław› Author AffiliationsRecommend Article Abstract PDF Download Buy Article Summary The fibrin clot induced by a minimum amount of thrombin contains two components: one which forms the fibrin polymer spontaneously and another which does not form the polymer except in the presence of thrombin. The latter component produces non-protein nitrogen like fibrinogen itself, when reacting with thrombin. It is reasonable to conclude that the fissile component of the clot is an intermediate product of the fibrin formation. PDF (1071 kb) References References 1 B’lombäck B, Vestermark A. Isolation of fibrino-peptides by chromatography. Ark. Kemi 1958; 12: 173 2 Buluk K, Małofiejew M. O stabilizacji włóknika czyli trzeciej fazie fibrynogenezy. Roczniki Akademii Medycznej im. Juliana Marchlewskiego w Bialymstoku 1955; 1: 159 3 Donnelly T. H, Laskowski Jr. M, Notley N, Scheraga H. A. Equilibria in the fibrinogen-fibrin conversion. II. Reversibility of the polymerisation steps. Arch. Biochem 1955; 56: 369 4 Kekwick R. A, Mackay M. E, Nance H, Record B. R. The purification of human fibrinogen. Biochem. J 1955; 60: 671 5 Kowarzyk H, Buluk K. Trombina, proteaza trombinowa i plazmina. Acta Physiol. Pol 1954; 5: 35 6 Kowarzyk H, Rechnic M, Siwińska M, Czerwińska B. Fibrynoliza krwi bydlęcej a trombinogeneza. Arch. Immunol. Ter. Dośw 1958; 6: 475 7 Laki K, Mihalyi E. Action of thrombin on iodinated fibrinogen. Nature 1949; 163: 66 8 Landaburu R. H, Seegers W. H. Proteolytic and polymerase activity of thrombin. The American Journal of Physiology 1960; 198: 173 9 Oppenheimer C, Pincussen L. Die Methodik der Fermente. Thieme; Leipzig: 1929
