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Thromb Haemost 1962; 07(02): 239-248
DOI: 10.1055/s-0038-1655472
Originalarbeiten — Original Articles — Travaux Originaux
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Partial Activation of Purified Prothrombin: Derivation of Autoprothrombin I with Use of Autoprothrombin C[*]

Walter H Seegers
1   Department of Physiology and Pharmacology, Wayne State University, College of Medicine, Detroit, Michigan, USA
,
Edmond R Cole
1   Department of Physiology and Pharmacology, Wayne State University, College of Medicine, Detroit, Michigan, USA
,
Ewa Marciniak   **
1   Department of Physiology and Pharmacology, Wayne State University, College of Medicine, Detroit, Michigan, USA
› Author Affiliations
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Publication History

Publication Date:
21 June 2018 (online)

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Summary

Activation of purified prothrombin with autoprothrombin C in the absence of calcium ions produces autoprothrombin I activity. The solubility, and stability properties of this autoprothrombin I are different from those of autoprothrombin I when obtained by activating prothrombin with calcium ions, platelet factor 3, and Ac-globulin.

* This investigation was supported by a research grant H-3424 from the National Heart Institute, National Institutes of Health, U.S. Public Health Service.


** The Rockefeller Foundation, Research Fellow.


 

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