Use of Factor VIII in the Treatment of Hemophilia^[*]

Summary

This publication describes the results obtained by treatment of haemophiliacs with factor VIII preparations isolated from Cohn fraction I by use of tannic acid, FI-O-Ta.

The authors stress the rapidity of the disappearance of factor VIII after injection. Transfusions are generally well tolerated. One reaction of the pyrogen type has been observed and also a case of activation of the fibrinolytic system.

A second purification method by means of chromatography on DEAE-cellulose is described.

• References

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• 3 Simonetti CCasillas, Pavlovsky A. Fibrinogene: préparation a partir du complexe fibrinogène-tanin. Rev. franç. Et. cliniques biol 1960; V: 925-926.
• 4 Pavlovsky A, Simonetti C, Casillas G, Bergna L, ino A, Bachmann A. E. The use of Factor VIII free from fibrinogen in the treatment of hemophilic patients. Brit. J. Hemat. 1961. (in press)
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