Subscribe to RSS
DOI: 10.1055/s-0038-1655471
Use of Factor VIII in the Treatment of Hemophilia[*]
Publication History
Publication Date:
21 June 2018 (online)
Summary
This publication describes the results obtained by treatment of haemophiliacs with factor VIII preparations isolated from Cohn fraction I by use of tannic acid, FI-O-Ta.
The authors stress the rapidity of the disappearance of factor VIII after injection. Transfusions are generally well tolerated. One reaction of the pyrogen type has been observed and also a case of activation of the fibrinolytic system.
A second purification method by means of chromatography on DEAE-cellulose is described.
* Laboratory of Biochemistry. National Cancer Institute. Institute National of Health, Bethesda.
Aided by grants from: The “Consejo Nacional de Investigaciones científicas y técnicas”, Fundación para la Hemofilia and Fundaleu.
-
References
- 1 Simonetti C, Casillas G, Pavlovsky A. Valoración de los métodos para purificar el Factor VIII. Symposium sobre Factor VIII. Acad. Nac. Med. Bs. As. Agosto 1959. (in press)
- 2 Simonetti C, Casillas G, Pavlovsky A. Purification du Facteur VIII antihémophilique (FAH). Hémostase 1961; I: 57-61.
- 3 Simonetti CCasillas, Pavlovsky A. Fibrinogene: préparation a partir du complexe fibrinogène-tanin. Rev. franç. Et. cliniques biol 1960; V: 925-926.
- 4 Pavlovsky A, Simonetti C, Casillas G, Bergna L, ino A, Bachmann A. E. The use of Factor VIII free from fibrinogen in the treatment of hemophilic patients. Brit. J. Hemat. 1961. (in press)
- 5 Creveld van S, Veder H. A, Pascha C. N, Kroeze W. F. The separation of AHF from Fibrinogen. Thromb. Diath. haem 1959; 3: 572-577.
- 6 Creveld van S, Veder H. A, Pascha C. N. The separation of AHF from Fibrinogen. II. Thromb. Diath. haem 1960; 4: 211-217.