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Thromb Haemost 1962; 07(01): 159-168
DOI: 10.1055/s-0038-1655462
Originalarbeiten — Original Articles — Travaux Originaux
Schattauer GmbH

The Coagulation Defect in Hypervitaminosis A in Rats[*]

L. G Israels
1   Departments of Medicine and Pediatrics, University of Manitoba, Winnipeg, Manitoba, Canada
,
J Foerster
1   Departments of Medicine and Pediatrics, University of Manitoba, Winnipeg, Manitoba, Canada
,
A Zipursky   **
1   Departments of Medicine and Pediatrics, University of Manitoba, Winnipeg, Manitoba, Canada
› Institutsangaben
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Publikationsdatum:
21. Juni 2018 (online)

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Summary

Rats fed vitamin A, 70 000 u daily for a period of 28 days developed a hemorrhagic state characterized by a prolonged prothrombin time and stypven time, a marked reduction in prothrombin and the factor VII-complex, and an inconstant decrease in factor V activity. A serum defect in thromboplastin generation was also noted. The defects in the extrinsic system were prevented by the simultaneous daily feeding of 60 μg to 120 μg of vitamin K1 but this did not uniformly prevent the serum defect in thromboplastin generation which is thought to represent a depletion in factor IX.

* This work was supported by a grant from the Manitoba Heart Foundation.


** With the technical assistance of Miss E. Friesen and Miss J. Skanderbeg.


 

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