Thromb Haemost 1962; 08(03): 442-454
DOI: 10.1055/s-0038-1655442
Originalarbeiten — Original Articles — Travaux Originaux
Schattauer GmbH

Is there a Hemostatic Effect of Peanuts in Hemophilioid Disorders?[*]

Pieter Brakman**
1   The James F. Mitchell Foundation, Institute for Medical Research, Washington Clinic, Washington 15, D.C., USA, and the Biological Institute, Carlsberg Foundation, Copenhagen, Denmark
,
Knud-Erik Sjølin***
1   The James F. Mitchell Foundation, Institute for Medical Research, Washington Clinic, Washington 15, D.C., USA, and the Biological Institute, Carlsberg Foundation, Copenhagen, Denmark
,
Tage Astrup****
1   The James F. Mitchell Foundation, Institute for Medical Research, Washington Clinic, Washington 15, D.C., USA, and the Biological Institute, Carlsberg Foundation, Copenhagen, Denmark
› Author Affiliations
Further Information

Publication History

Publication Date:
14 May 2019 (online)

Summary

1. Data on the effect of defatted peanuts in hemophilioid patients (deficient in Factor VIII or Factor IX) are presented.

2. Oral administration of peanuts is regularly followed by a decrease in spontaneous fibrinolytic activity of the blood.

3. A clinical effect of peanuts is limited and seems to be present only in mild disorders and in periods of mild relapse.

4. The data supports the concept that the peanut effect is indirect and is caused by an antiprotease delaying fibrinolysis.

* This investigation was supported by the Josiah Macy Jr. Foundation, New York, and by the U. S. Public Health Service, National Heart Institute (Grant HE-05020).


** Research Associate, Member, James F. Mitchell Foundation.


*** Lecturer in pathological Anatomy, University of Copenhagen, Denmark.


**** Director of Research, Chief, James F. Mitchell Foundation.


 
  • References

  • 1 Boudreaux H. B, Frampton V. L. A peanut factor for haemostasis in haemophilia. Nature (London) 1960; 185: 469
  • 2 Boudreaux H. B, Boudreaux R. M, Brandon M, Frampton V. L, Lee L. S. Bioassay of a hemostatic factor from peanuts. Arch. Biochem. 1960; 89: 276
  • 3 Schmutzler R. Die Wirkung von Erdnüssen (Arachis hypogaea) und Erdnußextrakten auf die Gerinnungsfaktoren. Thrombos. Diathes. haemorrh. 1961; 5: 566
  • 4 Astrup T, Brakman P, Ollendorff P, Rasmussen J. Haemostasis in haemophilia in relation to the haemostatic balance in the normal organism and the effect of peanuts. Thrombos. Diathes. haemorrh. 1960; 5: 329
  • 5 Creveld vanS., Mochtar I. A. Haemophilia and therapy with peanuts. Ann. paediat. 1961; 197: 1
  • 6 Nilsson I. M. Relationen mellan fettmetabolism. blodkoagulation och fibrinolys. Näringsforskning 1960; 4: 66
  • 7 Moers A. M. J, den Ollolander G. J. H. Hemofilie en therapie met pinda's. Ned. Geneesk. 1961; 105: 2241
  • 8 Astrup T, Brakman P, Sjølin K.-E. Haemophilia and the protease inhibitor in peanuts. Nature (London) 1962; 194: 980
  • 9 Verstraete M, Vermylen C, Devreker R. The influence of peanuts extracts on haemostasis. Proc. 8th Congress of the European Soc. of Haematology, Vienna 1961, Comm. No. 358. Karger, Basel.
  • 10 Astrup T, Müllertz S. The fibrin plate method for estimating fibrinolytic activity. Arch. Biochem. 1952; 40: 346
  • 11 Lassen M. Heat denaturation of plasminogen in the fibrin plate method. Acta physiol. scand. 1952; 27: 371
  • 12 Astrup T, Rasmussen J. Estimation of fibrinolytic activity in blood. Proc. 7th International Congress of the International Society of Hematology, Rome 1958; p. 164
  • 13 Sjølin K.-E. The thrombin generation test in the diagnosis of classical hemophilia and Christmas disease. Scand. J. clin. Lab. Invest. 1956; 8: 138
  • 14 Sjølin K.-E. Haemophilic Diseases in Denmark. Blackwell Scientific Publications; Oxford: 1960
  • 15 Astrup T, Ollendorff P. Estimation of thromboplastin activation in plasma. Scand. J. clin. Lab. Invest. 1961; 13: 377
  • 16 Astrup T, Albrechtsen O. K. Estimation of the plasminogen activator and the trypsin inhibitor in animal and human tissues. Scand. J. clin. Lab. Invest. 1957; 9: 233
  • 17 Vries deS. I., Braat-van Straaten M. A. J, Müller E, Wetter-mark M. Antiplasmin deficiency in polycythaemia: a form of thrombopathy. Thrombos. Diathes. haemorrh. 1961; 6: 445
  • 18 Fearnley G. R, Ferguson J, Chakrabarti R, Vincent C. T. Effect of beer on blood fibrinolytic activity. Lancet 1960; 1: 184
  • 19 Nilsson I. M, Björkman S. E, v. Studnitz W, Hallén A. Anti-fibrinolytic activity of certain pectins. Thrombos. Diathes. haemorrh. 1961; 6: 177
  • 20 Combs G. E, Wallace H. D. Peanut meal as a source of protein in pig starter and grower rations. J. animal Sci. 1962; 21: 95