Pathophysiologie, Diagnostik und aktuelle Therapie der tumorinduzierten Hämostasestörung

K. -H. Zurborn; H. D. Bruhn

doi:10.1055/s-0038-1655283

Hämostaseologie, Inhaltsverzeichnis

Hamostaseologie 1995; 15(01): 21-30
DOI: 10.1055/s-0038-1655283

Übersichtsarbeiten/Review Articles

Schattauer GmbH

Pathophysiologie, Diagnostik und aktuelle Therapie der tumorinduzierten Hämostasestörung

K. -H. Zurborn

¹I. Medizinische Universitätsklinik Kiel (Direktor: Prof. Dr. U. R. Fölsch)

,

H. D. Bruhn

¹I. Medizinische Universitätsklinik Kiel (Direktor: Prof. Dr. U. R. Fölsch)

› Institutsangaben

Abstract

Zusammenfassung

Neuere Erkenntnisse zur Pathophysiologie der Tumorthrombophilie verdeutlichen zunehmend die Komplexität. Verschiedene Tumoren unterscheiden sich deutlich bezüglich der Expression von Tumorprokoagulanzien, Komponenten des Fibrinolysesystems, Zytokin-vermittelter Beeinflussung von Entzündungszellen und Endothel und der plättchenaktivierenden Eigenschaften. Die Gerinnungsaktivierung mit Thrombinbildung geht über ein Epiphänomen deutlich hinaus. Dies wird durch zahlreiche tierexperimentelle und klinische Daten zur Beeinflussung des Tumorwachstums mit antithrombotischen Maßnahmen belegt. Darüber hinaus besteht eine autokrine mitogene Stimulation der Tumorzelle selbst durch das von ihr induzierte Thrombin, das auf diese Weise Tumorwachstum unterhalten kann. Auf diesem Boden werden aktuelle Therapiestrategien für ganz bestimmte Tumorarten einschließlich spezieller Probleme der Therapie mit Antikoagulanzien und Plättchenfunktionshemmern beim Tumorpatienten aufgezeigt.

Schlüsselwörter

Neoplasma - Tumorprokoagulanz - Thrombophilie - Akute-Phase-Reaktion - antithrombotische Therapie

Volltext

Referenzen

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