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Thromb Haemost 1965; 14(01/02): 145-158
DOI: 10.1055/s-0038-1654860
Originalarbeiten — Original Articles — Travaux Originaux
Schattauer GmbH

A Comparative Study of the Inhibitors of Fibrinolysis in Human, Dog and Rabbit Blood

M. J Gallimore
1   Department of Pharmacology, Pfizer Ltd., Sandwich, Kent, England
,
M. V Nulkar
1   Department of Pharmacology, Pfizer Ltd., Sandwich, Kent, England
,
JTB Shaw
1   Department of Pharmacology, Pfizer Ltd., Sandwich, Kent, England
› Author Affiliations
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Publication History

Publication Date:
27 June 2018 (online)

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Summary

Comparison of sera from dog, rabbit and man shows that dog serum contains most fibrinolytic inhibitor and human serum least. The inhibitors are potentiated by a variety of inorganic salts, of which sodium chloride is most effective. Euglobulin fractions precipitated from rabbit and human plasma at pH 5.3 contain small amounts of inhibitory material, whereas little remains in the corresponding dog euglobulin or in euglobulins from all three species when precipitated at pH 6.0. The potentiation of fibrinolytic inhibitors by sodium chloride differs between the three species, suggesting that their composition is not identical. Chloroform extraction removes a proportion of the inhibitory material from each serum.

 

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