Thromb Haemost 1963; 10(01): 146-150
DOI: 10.1055/s-0038-1654770
Originalarbeiten — Original Article — Travaux Originaux
Schattauer GmbH

The Effect of Aminopterin Sodium on Plasma Fibrinogen, Antifibrinolysin and Euglobulin Lysis Time[*]

J Frederic Johnson
1   Department of Physiology and Pharmacology, Wayne State University College of Medicine, Detroit, Michigan, USA
,
Rashid A Zeineh
1   Department of Physiology and Pharmacology, Wayne State University College of Medicine, Detroit, Michigan, USA
› Author Affiliations
Further Information

Publication History

Publication Date:
22 June 2018 (online)

Summary

The daily oral administration of Aminopterin Sodium to normal dogs was accompanied by an increase in plasma antifibrinolysin concentration, an increase in plasma fibrinogen concentration and a decrease in euglobulin fibrinolytic activity.

* This investigation was supported by a research grant HE-05141 from the National Heart Institute, National Institute of Health, U.S. Public Health Service.


 
  • References

  • 1 Guest M. M, Ware A. G, Seegers W. H. A Quantitative Study of Antifibrinolysin in Chick Plasma: Increase in Antifibrinolysin Activity During Pteroylglutamic Acid Deficiency. Amer. J. Physol. 150: 661 1947;
  • 2 Dameshek W, Freedman M. H, Steinberg L. Folic Acid Antagonists in the Treatment of Acute and Subacute Leukemia. Blood 05: 898 1950;
  • 3 Stirland R. M, Camb M. B. A Rapid Method of Estimating Fibrinogen. Lancet 01: 672 1956;
  • 4 Ware A. G, Guest M. M, Seegers W. H. Fibrinogen: With Special Reference to its Preparation and Certain Properties of the Product. Arch. Biochem. 13: 231 1947;
  • 5 Kowalskij E, Kopec M, Niewiarowski S. An Evaluation of the Euglobulin Method for the Determination of Fibrinolysis. J. clin. Path. 12: 215 1959;
  • 6 Fearnley G. R. Spontaneous Fibrinolysis. Amer. J. of Cardiol. Symposium on Fibrinolysis. 371 August 1960
  • 7 Whipple G. H, Hurwitz S. F. Fibrinogen of the Blood as Influenced by the Liver Necrosis of Chloroform Poisoning. J. exp. Med. 13: 136 1911;
  • 8 Elliot F. A, Buckel M. Fibrinogen Changes in Relation to Cerebrovascular Accidents. Neurology 11: 120 1961;
  • 9 Ingram G. I. C. Plasma Fibrinogen Concentration in Occlusive Arterial Disease. Edinb. med. J. 59: 94 1952;
  • 10 Adelson E, Rheingold J. J, Parker O, Buenaventura A, Crosby W. H. Platelets and Fibrinogen Survival in Normal and Abnormal State of Coagulation. Blood 17: 267 1961;
  • 11 Gerdes K, Maurer W. Evaluation of the Life Span of Fibrinogen in Man and Rabbit. Biochem. Z. 328: 552 1957;
  • 12 Hammond J. D. S, Verel D. Observations on the Distribution and Biological Half-life of Human Fibrinogen. Brit. J. Haemat. 05: 431 1959;
  • 13 Madden R. E, Gould R. G. The Turnover Rate of Fibrinogen in the Dog. J. biol. Chem. 196: 641 1952;
  • 14 Volwiler W, Goldsworthy P. D, MacMartin M. P, Wood P. A, MacKay I. R, Fermont-Smith K. Biosynthetic Determination with Radioactive Sulfur of Turn-over Rates of Various Plasma Proteins in Normal and Cirrhotic Man. J. clin. Invest. 34: 1126 1955;