Antifibrinolytic Activity of Certain Pectins^[*]

Summary

Ingestion of wine and beer, but not of ethyl alcohol, produced a decrease of the blood fibrinolytic activity. In vitro experiments showed that wine and beer contained a principle which inhibited fibrinolytic activators. This principle was isolated from grape pulp, and upon analysis it was found to be a pectin-like substance.

^* This investigation was supported by grants from the Swedish Medical Research Council.

• References

• (1) Astrup T, Albrechtsen O. K. Estimation of the plasminogen activator and the trypsin inhibitor in animal and human tissues. Scand. J. clin. Lab. Invest. 9: 233 1957;
• (2) Brahn B, Klarenbeek A, Langner T. Onderzoek over een nieuw bloed-stollingsmiddel. Nederland. T. soc. Geneesk. 37: 4362 1935;
• (3) Fearnley G. R, Ferguson J, Chakrabarti R, Vincent C. T. Effect of beer on blood fibrinolytic activity. Lancet 1: 184 1960;
• (4) Hottenroth B. Die Pektine und ihre Verwendung. 67 Oldenbourg; München: 1951
• (5) Joseph G. H. Medical literature on pectin and pectin pastes. Bull. nat. Formulary Comm. 9: 2 1940;
• (6) Kertesz Z. I. The Pectic Substances. Interscience Publishers; 92 Inc. New York:
• (7) Marx R. Beitrag zur experimentellen Untersuchung des Mechanismus der Wirkung von Pektin auf Blutgerinnung und Blutstillung und zum Studium des verhaltens von Pektin im Stoffwechsel. Dissertation München: 1939
• (8) Nilsson I. M, Blombäck M, Francken I. V. On an inherited autosomal hemorrhagic diathesis with antihemophilic globulin (AHG) deficiency and prolonged bleeding time. Acta med. scand. 159: 35 1957;
• (9) Nilsson I. M, Krook H, Sternby N.-H, Soüderberg E, Söder-ström N. Severe thrombotic disease in a young man with bone marrow and with a high content of an inhibitor in the fibrinolytic system. Acta med. scand. 169: 323 1961;
• (10) Nilsson I. M, Sjoerdsma A, Waldenström J. Antifibrinolytic activity and metabolism of ε-aminocaproic acid in man. Lancet 1: 1322 1960;
• (11) Porath J, Flodin P. Gel filtration: a method for desalting and group separation. Nature 183: 1657 1959;
• (12) Sherry S, Lindemeyer R. I, Fletcher A. P, Alkjaersig N. Studies on enhanced fibrinolytic activity in man. J. clin. Invest. 38: 810 1959;
• (13) Reisser O, Nagel A. Über die gerinnungsfördernde Wirkung saurer Substanzen, insbesondere des Pektins. Arch. exp. Pathol. Pharmakol. 179: 748 1935;
• (14) Wieland T, Pfleiderer G. Analytische und mikropräparative Trägerelektrophorese mit höheren Spannungen. Angew. Chem. 67: 257 1955;