Influence of Organ Extracts on Blood Clotting Factors

Summary

Brain and lung suspensions incubated with blood or serum produce sera which are deficient in factor IX and factor VII.

Suspensions prepared from acetone-dehydrated brain are effective substitutes for free phospholipids in the formation of blood thromboplastin.

The fraction which inactivates the clotting factors is connected with a readily sedimentable portion of the brain suspension.

It is heat stable, and destroyed by ethanol-ether extraction.

The extracted lipid is inactive.

^*) This investigation was supported by a grant from the National Health and Medical Research Council of Australia.

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