Thromb Haemost 1970; 24(01/02): 152-160
DOI: 10.1055/s-0038-1654220
Originalarbeiten – Original Articles – Travaux Originaux
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Corrective Effect of Sialic Acid on the Clotting of Factor VIII Deficient Blood

H Rubin
1   Division of Hematology, Department of Medicine, Maimonides Medical Center, Brooklyn, New York, and the State University of New York, Downstate Medical Center, Brooklyn, New York
,
T Fernbach
1   Division of Hematology, Department of Medicine, Maimonides Medical Center, Brooklyn, New York, and the State University of New York, Downstate Medical Center, Brooklyn, New York
,
N. D Ritz
1   Division of Hematology, Department of Medicine, Maimonides Medical Center, Brooklyn, New York, and the State University of New York, Downstate Medical Center, Brooklyn, New York
› Institutsangaben

These studies were supported by grants from the Metropolitan Chapter of the National Hemophilia Foundation and Brooklyn Hemophilia Guild.
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Publikationsdatum:
28. Juni 2018 (online)

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Summary

Optimal concentrations of N-acetyl neuramic acid (NANA) accelerated the clotting of factor VIII deficient whole blood and plasma. There was no effect on normal plasma and certain other factor deficient plasmas.

NANA increased thromboplastin formation by factor VIII deficient plasma, as measured by the Thromboplastin Generation Test.

NANA possesses an inhibitory effect on rabbit brain thromboplastin and cephalin in recalcification tests, over the values of its controls, but-in sharp contrast, enhanced the effect of Russell Viper Venom (RVV) and RVV-cephalin.

The amino sugar N-acetyl mannosamine, possessing common functional groups with NANA, also shortened the clotting time of factor VIII deficient whole blood and plasma.

It is suggested that NANA acts as a cofactor to factor VIII which is present in trace amounts in hemophilic plasma.