Thrombosis and Haemostasis, Inhaltsverzeichnis Thromb Haemost 1970; 24(01/02): 043-047DOI: 10.1055/s-0038-1654209 Originalarbeiten – Original Articles – Travaux Originaux Schattauer GmbH Persistence of Fibrinolytic Activity in Fragments of Human Veins Cultured in Vitro M Pandolfi 1 Coagulation Laboratory, Malmö General Hospital, University of Lund (Sweden) and the Embryological Institute, University of Lund (Siveden)› InstitutsangabenArtikel empfehlen Abstract Artikel einzeln kaufen Summary Explants from 5 adult human veins were cultured in a fibrinolytically inactive medium for 3 weeks and assayed for the presence of plasminogen activator by the fibrin slide technique. The explants from 3 veins showed fibrinolytic activity confined to their vasa vasorum for the whole duration of the culture; no decrease of activity was seen. The finding suggests that small blood vessels are able to synthesize plasminogen activator. Volltext Referenzen References 1 Astrup T. Tissue activators of plasminogen. Fed. Proc 25: 42-51 1966; 2 Astrup T. Blood coagulation and fibrinolysis in tissue culture and tissue repair. Biochemica Pharmacology, Suppl. Pergamon; London: 1968: 241-257. 3 Astrup T, Müllertz S. The fibrin plate method for estimating fibrinolytic activity. Arch. Biochem 40: 346-351 1952; 4 Bernik M. B, Kwaan H. G. Origin of fibrinolytic activity in cultures of the human kidney. J. Lab. clin. Med 70: 650-661 1967; 5 Bernik M. B, Kwaan H. C. Plasminogen activator activity in cultures from human tissues. An immunological and histochemical study. J. clin. Invest 48: 1740-1753 1969; 6 Brakman P. Fibrinolysis. A standardized fibrin plate method, and a fibrinolytic assay of plasminogen. Scheltema & Holkema; Amsterdam: 1967 7 Clarke R. L, Orandi A, Cliffton E. E. Induction of fibrinolysis by venous obstruction. Angiology 11: 367-370 1960; 8 Fearnley G. R. Fibrinolysis. Williams and Wilkins; Baltimore: 1965 9 Holemans R. Enhancement of fibrinolysis in the dog by injection of vasoactive drugs. Amer. J. Physiol 208: 511-520 1965; 10 Muellertz S. Activation of plasminogen. Ann. N.Y. Acad. Sci 68: 38-45 1957; 11 Painter R. H, Charles A. F. Characterization of a soluble plasminogen activator from kidney cell cultures. Amer. J. Physiol 202: 1125-1130 1962; 12 Pandolfi M, Robertson B, Isacson S, Nilsson I. M. Fibrinolytic activity of human veins in arms and legs. Thrombos. Diathes. haemorrh. (Stuttg.) 20: 247-256 1968; 13 Sjoerdsma A, Nilsson I. M. Aliphatic amino coompounds as inhibitors of plasminogen activation. Proc. Soc. exp. Biol. (N. Y.) 103: 533-535 1960; 14 Todd A. S. Histological localization of fibrinolysin activator. J. Path. Bact 78: 281-283 1959;
