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Thromb Haemost 1967; 17(03/04): 482-490
DOI: 10.1055/s-0038-1654172
DOI: 10.1055/s-0038-1654172
Originalarbeiten - Original Articles - Travaux Originaux
Influence of Plasma Lipoproteins on the Fibrinolytic Activity
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Publication History
Publication Date:
26 June 2018 (online)
Summary
Native lipoprotein fractions : alpha, beta and chylomicrons have been isolated from human serum according to the method of Burstein. Alpha lipoproteins and chylomicrons do not inhibit plasmin. The antiplasmin activity of beta lipoprotein amounts to about 10% of the total plasma antiplasmin activity. It is inactivated during heating at 56° C for 10 min, while storing at 4° C for a few days and by chloroform treatment. About 50% of serum beta lipoprotein is precipitated in euglobulin fraction. Variations of serum beta lipoprotein level have a significant effect on euglobulin fibrinolysis. Beta lipoprotein level, beta lipoprotein antiplasmin activity and euglobulin fibrinolysis have been determined in 2 groups of lipemic patients : a) puerperal women, b) patients with advanced atherosclerosis. There is a close correlation of beta lipoprotein level and euglobulin fibrinolysis time in puerperal patients. The inhibition of euglobulin fibrinolysis in patients with atherosclerosis depends on several factors, and only partly of the beta lipoprotein level. Beta lipoprotein level and beta lipoprotein antiplasmin activity were well correlated in both groups of patients.
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References
- 1 Bang N. U, Cliffion E. E. The effect of alimentary hyperlipemia on thrombolysis in vivo Thrombos. Diathes. haemorrh. (Stuttg.) 4: 149 1960;
- 2 Billimoria J. D, James J, Drysdale D. G. O, Maclagan N. F. Determination of fibrinolytic activity of whole blood. Lancet II: 471 1959;
- 3 Blix S. Studies on the fibrinolytic system in the euglobulin fraction of human plasma. Scand. J. clin. Lab. Invest. 13 58 1961
- 4 Buckell M, Elliot F. A. Effect of butter lipaemia on the rate of clot lysis in normal males. Lancet 1: 662 1959;
- 5 Burstein M, Fine J. M. Isolement d’une fraction des alpha1-ipoproteines sèriques après précipitation par le sulfate de dextrane en présence des cations bivalents et de saccharose. Rev. franç. Étud. clin. biol 9: 195 1964;
- 6 Burstein M, Samaille J. Nouvelle methode de séparation et de dosage des lipoprotéines de faible densité. Ann. biol. Clin 17: 23 1959;
- 7 Burstein M, Samaille J. Dosage des beta-lipoproteines sèriques après précipitation sélective par l’héparine. Presse méd 66: 974 1958;
- 8 Christensen L. R. Activation of plasminogen by chlorofrom. J. gen. Physiol 30: 149 1947;
- 9 Delezenne C, Pozerski E. Action du sérum sanguin sur la gélatine en présence du chloroforme. C. R. Soc. Biol. (Paris) 55: 327 1903;
- 10 Denys J, Marbaix H. Sur les peptonisations provoquées par le chlorofrome et quelques autres substances. Cellule 5: 193 1889;
- 11 Farquhar J. W, Merigan T. G, Sokolow M. Plasma fibrinolysis in man: the effect of chylomicrons derived from different deitary fats. J. exp. Med 113: 587 1961;
- 12 Gillman T, Naidoo S. S, Hathorn M. Fat, fibrinolysis and atherosclerosis in Africans. Lancet II: 696 1957;
- 13 Greig H. B. W. Inhibition of fibrinolysis by alimentary lipaemia. Lancet II: 16 1956;
- 14 Greig H. B. W, Runde J. A. Studies on the inhibition et fibrinolysis by lipids. Lancet II: 461 1957;
- 15 Hougie G, Ayers F. Lipaemia and fibrinolytic potentiality. Lancet I: 186 1960;
- 16 Howell M. Effects of plasma lipids on fibrinolysis. Brit. med. Bull 20: 200 1964;
- 17 Jacobsen C. D. The caseinolytic method for determination of plasminogen-plasmin in human plasma and serum. Scand. J. clin. Lab. Invest 16: 372 1964;
- 18 Kekwick R. A, MacKay N. E, Nance M. H, Record B. R. The purification of human fibrinogen. Biochem. J 60: 671 1955;
- 19 Konttinen Y. On the effect of alimentary lipaemia and a natural heparinoid on the fibrinolytic system of man. Scand. J. clin. Lab. Invest 14: 87 1961;
- 20 Kowalski E, Kopec M, Niewiarowski S. An evaluation of the euglobulin method for the determination of fibrinolysis. J. clin. Path 12: 215 1959;
- 21 Lackner H. Sougin-Mibashan Fibrinolysis in relation to lipaemia and intravenous heparin in the White and Bantu. S. Afr. med. J 35: 364 1961;
- 22 Lewis J. H, Ferguson J. H. Studies on a proteolytic enzyme system of the blood. IV. Activation of Profibrinolysin by serum fibrinolysokinase. Proc. Soc. exp. Biol. (N. Y.) 78: 184 1951;
- 23 Moga A, Baciu I, Pitea P, Cucuianu M, Suciu A. Sistemul fibrinolytic synguin in atheromatoza umana. Stud. Cercet. Med. (Cluj) 11: 97 1960;
- 24 Moser K. M, Hajjar G. C. Age and disease related alterations in fibrinogeii-euglobulin (fibrinolytic) behaviour. Amer. J. med. Sci 251: 536 1966;
- 25 Niewiarowska M, Węgrzynowicz Z. Influence of dicoumarol derivatives on plasma fibrinolytic system. Thrombos. Diathes. haemorrh. (Stuttg.) 3: 279 1959;
- 26 Nitzberg S. I, Peyman M. A, Goldstein R, Proger S. Studies of blood coagulation and fibrinolysis in patients with idiopathic hyperlipemia and primary hypercholesteremia before and after a fatty meal. Circulation 19: 676 1959;
- 27 Ogston D, Fullerton H. W. Effect of alimentary lipaemia on plasma fibrinolytic activity. Brit. med. J 2: 1288 1962;
- 28 Pappenhagen A. R, Koppel J. L, Olwin J. H. Observations on the in vitro effects of chylomicra low-density lipoproteins and phospholipids on human plasma euglobulin lysis. Thrombos. Diathes. haemorrh. (Stuttg.) 9: 164 1963;
- 29 Riding I. M, Ellis D. Antiplasmin activity of beta-lipoprotein. J. Atheroscler. Res 4: 189 1964;
- 30 Sarkar N. Reduced fibrinolytic activity of atherosclerotic sera caused by an increase in low-density lipoproteins in blood. Nature 189: 929 1961;
- 31 Shamash Y, Rimon A. The plasmin inhibitors of plasma. I. A method for their estimation. Thrombos. Diathes. haemorrh 12: 119 1964;
- 32 Shaper A. G, Jones K. W, Kyobe J, Jones M. Fibrinolysis in relation to body fatness, serum lipids and coronary heart disease in African and Asian men in Uganda. J. Atheroscler. Res 6: 313 1966;
- 33 Skrzydlewski Z, Niewiarowski S, Skrzydlewska J. Inhibition of proteolytic enzymes by beta-lipoprotein. J. Atheroscler. Res 6: 273 1966;
- 34 Sweet B, Rifkind B. M, McNicol G. P. The relationship between blood lipids and the fibrinolytic enzyme system. J. Atheroscler. Res 6: 359 1966;
- 35 Tagnon H. J, Davidson C. S, Taylor F. H. L. Studies of blood coagulation. A proteolytic enzyme prepared from calcium and platelet free normal human blood plasma. J. clin. Invest 22: 525 1942;
- 36 Walker A. R. P. Fibrinolytic activity of whole blood from south African Bantu and White subjects. Amer. J. clin. Nutr 9: 461 1961;